EFFECTS OF β-ADRENOCEPTOR BLOCKADE ON PROSTACYCLIN MEDIATED RENIN RELEASE IN SHEEP |
| |
| Authors: | R. T. Mason J. P. Coghlan D. A. Denton D. W. T. Fei J. A. Whitworth B. A. Scoggins |
| |
| Affiliation: | Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne,;*Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia |
| |
| Abstract: | 1. The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep. 2. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 μg/kg per min) produced dose dependent increases in PRC. 3. There was a significantly lower PRC response after propranolol at 0.3 μg/kg per min only. |
| |
| Keywords: | β-adrenoceptor, haemodynamics, isoprenaline, propranolol, prostacyclin, renin, sheep. |
|
|
