| 糖尿病大鼠脑缺血再灌注海马CA4区神经元中磷酸化ERK1/2的表达上调 |
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| 引用本文： | 马轶,景丽,郭凤英,张建中. 糖尿病大鼠脑缺血再灌注海马CA4区神经元中磷酸化ERK1/2的表达上调[J]. 第三军医大学学报, 2009, 31(23): 2312-2314 |
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| 作者姓名： | 马轶 景丽 郭凤英 张建中 |
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| 作者单位： | 宁夏医科大学基础学院病理学系,银川,750004;宁夏医科大学基础学院病理学系,银川,750004;宁夏医科大学基础学院病理学系,银川,750004;宁夏医科大学基础学院病理学系,银川,750004 |
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| 基金项目： | 国家自然科学基金，宁夏高等学校科研项目，宁夏医科大学面上项目 |
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| 摘 要： | 目的 探讨细胞外信号调节激酶1/2(extracellular signal-regulated kinase 1/2,ERK1/2)在糖尿病脑缺血再灌注大鼠海马CA4区神经元表达的意义.方法 在链脲佐菌素性糖尿病大鼠脑缺血再灌注模型基础中,应用TUNEL、免疫组化方法 观察糖尿病脑缺血组与正常血糖脑缺血组在全脑缺血15 min、再灌注1 h海马CA4区神经元凋亡和磷酸化ERK1/2(P-ERK1/2)的表达变化.结果 糖尿病脑缺血组在缺血15 min、再灌注1 h海马CA4区神经元凋亡发生率均明显高于正常血糖脑缺血组(P<0.05);糖尿病脑缺血组各时间点磷酸化ERK1/2明显增高,于再灌注1 h明显高于正常血糖组(P<0.01).结论 糖尿病加重脑缺血再灌注神经元的损伤,其机制可能与ERK1/2的激活有关.
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| 关 键 词： | 糖尿病 脑缺血再灌注损伤 细胞外信号调节激酶(ERK1/2) 海马 凋亡 |
Phosphorylized ERK1/2 is upregulated in diabetic rats after global cerebral ischemia-reperfusion injury |
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| MA Yi,JING Li,GUO Feng-ying,ZHANG Jian-zhong. Phosphorylized ERK1/2 is upregulated in diabetic rats after global cerebral ischemia-reperfusion injury[J]. Acta Academiae Medicinae Militaris Tertiae, 2009, 31(23): 2312-2314 |
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| Authors: | MA Yi JING Li GUO Feng-ying ZHANG Jian-zhong |
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| Affiliation: | MA Yi,JING Li,GUO Feng-ying,ZHANG Jian-zhong (Department of Pathology,Basic Medical College,Ningxia Medical University,Yinchuan 750004,China) |
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| Abstract: | Objective To explore the expression of extracellular signal-regulated kinase 1/2 (ERK1/2) in the hippocampus CA4 region of diabetic rats after global cerebral ischemia-reperfusion injury. Methods Diabetic rat was established by intraperitoneal injection of streptozocin (STZ) and then global cerebral ischemia model was induced by bilateral clamping of the carotid arterial plus hypotension by withdrawing blood. Apoptosis of neuron and expression of the phosphorylation of ERK1/2 (P-ERK1/2)were observed in the ... |
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| Keywords: | diabetes cerebral ischemia-reperfusion injury extracellular signal-regulated kinase1/2 hip-pocampus apoptosis |
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