| 去甲基化药物地西他滨治疗血液系统恶性肿瘤的研究进展 |
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| 引用本文： | 柯晴,岑洪,胡晓桦. 去甲基化药物地西他滨治疗血液系统恶性肿瘤的研究进展[J]. 医学综述, 2010, 16(7) |
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| 作者姓名： | 柯晴 岑洪 胡晓桦 |
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| 作者单位： | 广西医科大学附属肿瘤医院化疗三科,南宁,530021 |
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| 基金项目： | 广西医科大学"十一五"教育教学改革项目 |
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| 摘 要： | 随着对肿瘤表观遗传学的深入研究,发现DNA甲基化异常在血液肿瘤的发生和转化中起着重要作用。地西他滨是一种去甲基化药物,基础和临床研究发现其具有抑制甲基化转移酶的作用,在骨髓增生异常综合征和白血病的治疗中取得了很好的疗效,地西他滨的表观遗传学治疗在恶性肿瘤治疗中的地位也日益重要。
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| 关 键 词： | 地西他滨 去甲基化 骨髓增生异常综合征 白血病 |
Treatment Evolution in Hematopoietic Malignancies with an Hypomethylating Agent Decitabine |
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| KE Qing,CEN Hong,HU Xiao-hua.. Treatment Evolution in Hematopoietic Malignancies with an Hypomethylating Agent Decitabine[J]. Medical Recapitulate, 2010, 16(7) |
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| Authors: | KE Qing CEN Hong HU Xiao-hua. |
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| Affiliation: | KE Qing,CEN Hong,HU Xiao-hua.(Department of Chemotherapy,Guangxi Cancer Hospital of Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | DNA methylation play an important role during the maliganant transformation of hematopoietic malignancies.Decitabine is a hypomethylating agent which incorporate into DNA and lead to trapping and depletion of the enzyme DNA methyltransferase.Additionally,decitabine is an active therapy for myelodysplastic syndromes and leukemia.The epigenetic effect of decitabine will likely extend its use for the treatment of other malignancies. |
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| Keywords: | Decitabine Hypomethylation Myelodysplastic syndromes Leukemia |
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