| 脑出血大鼠脑组织神经肽Y水平的变化及意义 |
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| 引用本文： | 许志强,蒋晓江,陈曼娥,王景周.脑出血大鼠脑组织神经肽Y水平的变化及意义[J].中国临床神经科学,2002,10(2):133-135. |
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| 作者姓名： | 许志强 蒋晓江 陈曼娥 王景周 |
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| 作者单位： | 第三军医大学大坪医院神经内科三病区,400042 |
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| 基金项目： | 重庆市卫生局医学科研重点项目( 2 0 0 1 2 0 0 3) |
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| 摘 要： | 目的 :探讨脑出血过程中中枢神经系统神经肽Y(NPY)含量的动态变化及意义。方法 :采用胶原酶和肝素联合注入尾状核的方法建立大鼠脑出血模型 ,测定出血前、出血后 30min ,6、1 2、2 4、48及 72h血肿周边、下丘脑及脑干NPY的活性。结果 :脑出血后血肿周边、下丘脑及脑干NPY的含量同步升高 ,并于 2 4h达峰值 ,48～ 72h开始回落 ,但仍显著高于出血前 (P <0 0 1 )。结论 :脑出血过程中 ,脑组织NPY活性增强 ,导致局部脑血流量减少 ,最终加重神经细胞损害
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| 关 键 词： | 脑出血 神经肽Y 血肿周边 下丘脑 脑干 |
| 文章编号： | 1008-0678(2002)02-0133-03 |
| 修稿时间： | 2001年10月16 |
The Significance of Changes in Neuropeptide Y Activity in Brain Tissue During intracerebral Hemorrhage in Rats |
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| XU Zhi Qiang,CHEN Man E,JIANG Xiao Jiang,WANG Jing Zhou.The Significance of Changes in Neuropeptide Y Activity in Brain Tissue During intracerebral Hemorrhage in Rats[J].Chinese Journal of Clinical Neurosciences,2002,10(2):133-135. |
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| Authors: | XU Zhi Qiang CHEN Man E JIANG Xiao Jiang WANG Jing Zhou |
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| Institution: | XU Zhi Qiang,CHEN Man E,JIANG Xiao Jiang,WANG Jing Zhou. The Third Department of Neurology,Daping Hospital,The Third Military Medical University,Chongqing 400042,China |
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| Abstract: | Aim:To evaluate the significance of changes in neuropeptide Y(NPY) activity in brain tissue during experimental intracerebral hemorrhage(ICH).Methods:The ICH was established by infusing collagenase and heparin into rat caudate.We observed the changes of NPY in perihemotoma,hypothalamus and brainstem at preoperation,30 min,6 h,12 h,48 h and 72 h postoperation,respectively.Results:NPY activity in perihemotoma,hypothalamus and brainstem increased synchronously after cerebral hemorrhage,and peaked at 24 h,then began to reduce in 48 h to 72 h,but it was still higher than that of preoperation.Conclusion:During cerebral hemorrhage,the enhanced NPY activity in brain may reduce the regional cerebral blood flow,hence aggravate neural damage. |
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| Keywords: | cerebral hemorrhage neuropeptide Y perihemotoma hypothalamus brainstem |
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