| 内皮祖细胞在急性肺损伤中应用的研究进展 |
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| 引用本文： | 郭桢楠,马雪,丁文刚.内皮祖细胞在急性肺损伤中应用的研究进展[J].中国现代医学杂志,2021,31(3):65-69. |
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| 作者姓名： | 郭桢楠 马雪 丁文刚 |
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| 作者单位： | （哈尔滨医科大学附属第二医院 麻醉科，黑龙江 哈尔滨 150001） |
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| 基金项目： | 黑龙江省博士后科研启动金（No：LBH-Q14112） |
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| 摘 要： | 急性肺损伤是由各种肺内外因素导致的进行性呼吸困难和难治性低氧血症,其病理特征包括炎症反应及肺泡-毛细血管屏障功能破坏,微循环血管内皮损伤是主要标志.内皮祖细胞可以从骨髓动员迁移到损伤部位,分化为成熟内皮细胞发挥直接修复作用,并通过间接免疫调节作用改善微环境.此外内皮祖细胞还可以分泌细胞因子以自分泌或旁分泌方式促进新生血...
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| 关 键 词： | 急性肺损伤 内皮祖细胞 内皮修复 |
| 收稿时间： | 2020/8/9 0:00:00 |
Research progress on application of endothelial progenitor cells in
acute lung injury* |
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| Zhen-nan Guo,Xue M,Wen-gang Ding.Research progress on application of endothelial progenitor cells in
acute lung injury*[J].China Journal of Modern Medicine,2021,31(3):65-69. |
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| Authors: | Zhen-nan Guo Xue M Wen-gang Ding |
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| Institution: | (Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University,
Harbin, Heilongjiang 150000, China) |
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| Abstract: | ALI (Acute lung injury, ALI) is an acute progressive dyspnea and refractory hypoxemia caused by
a variety of internal and external pulmonary factors. Inflammation and destruction of alveolar-capillary barrier are
the main pathological characters of ALI, in which endothelial injury of microcirculation is the hallmark. Mobilizing
from bone marrow, EPC (endothelial progenitor cell, EPC) can migrate towards the sites of vascular injuries and
differentiate into mature endothelium to play a direct repair role and improve microenvironment through indirect
immunomodulation. In addition , EPC also secrete cytokines that promote angiogenesis in an autocrine or paracrine
manner. Thereby, alleviating organ dysfunction. This article is dedicated to describe the application of EPC in ALI
to provide new insight for treatment of ALI. |
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| Keywords: | acute lung injury endothelial progenitor cells endothelial repair |
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