急性脑梗死患者外周血中性粒细胞/淋巴细胞比值与颈动脉易损斑块的关系

目的 探讨急性脑梗死(ACI)外周血中性粒细胞/淋巴细胞比值(NLR)与颈动脉易损斑块的关系.方法 选取2016年9月—2018年1月于哈尔滨医科大学附属第一医院卒中病房住院的ACI患者271例.根据颈动脉超声检查分为无斑块组及有斑块组,其中有斑块组分为稳定斑块组及易损斑块组,比较各组一般资料,中性粒细胞计数、淋巴细胞...

The Relationship between neutrophil-to-lymphocyte ratioNLR andvulnerable plaque of carotid artery plaque in patients withAcute Cerebral iInfarction

Objective To study the association of neutrophil-to-lymphocyte ratio (NLR) with vulnerablecarotid artery plaque in patients with acute cerebral infarction (ACI). Methods The clinical data and bloodbiochemical data of 271 ACI patients in Department of Neurology were collected. According to carotidultrasonography, 271 patients with ACI were divided into non-plaque group and plaque group. The plaque group wassubdivided into stable plaque group and vulnerable plaque group according to the ultrasound features of plaques. Thegeneral clinical data, neutrophil counts, lymphocyte counts, and NLR were compared between groups. Results Thenumber of patients with smoking history, neutrophil counts, and NLR values in the plaque group were higher thanthose in the non-plaque group (P < 0.05), whereas lymphocyte counts in the plaque group were lower than those inthe non-plaque group (P < 0.05). The NLR, neutrophil counts, and low-density lipoprotein cholesterol (LDL-C) werehigher in the vulnerable plaque group than those in the stable plaque group (P < 0.05), while lymphocyte counts inthe vulnerable plaque group were lower than those in the stable plaque group (P < 0.05). Logistic regression analysis showed that the NLR [OR = 1.400 (95% CI: 1.124, 1.744)] and LDL-C [OR = 2.867 (95% CI: 1.238, 6.640)] wereindependent risk factors for vulnerable plaques in patients with ACI. The area under the receiver operatingcharacteristic (ROC) curve of NLR in predicting vulnerable plaques in patients with ACI was 0.65 (95% CI: 0.567,0.728). The optimal cut-off point was 2.79, and the sensitivity was 0.69 (95% CI: 0.593, 0.777) whereas thespecificity was 0.59 (95% CI: 0.465, 0.684). Conclusions The increase of NLR level is of value for evaluatingvulnerable carotid artery plaques in ACI patients.