糖尿病性轻度认知障碍患者体感诱发电位的特征和规律研究

目的 利用体感诱发电位（SEP）技术对认知功能状态进行客观评价。方法 对符合纳入标准的30例健康受试者、30例无认知障碍及30例轻度认知障碍的糖尿病患者进行体感诱发电位检测,记录周围神经电位、脊髓电位、皮层电位峰潜伏期等相关数据,并进行比较。结果 3组受试者SEP周围神经诱发电位、皮层下电位峰潜伏期比较,差异无统计学意义（P?>0.05）,轻度认知障碍组的皮层电位峰潜伏期、中枢传导时间与正常组和无认知障碍组比较,差异有统计学意义（P?<0.05）。无认知障碍组的中长潜伏期P60、N75峰潜伏期与正常组比较,差异有统计学意义（P?<0.05）,而中枢传导时间比较,差异无统计学意义（P?>0.05）。结论 SEP皮层电位对认知功能的评价更具敏感性,优于量表评估,可用于评估糖尿病性轻度认知障碍的亚临床病变。且胫后神经SEP皮层电位对糖尿病性轻度认知障碍的亚临床期及早期评价较正中神经SEP更有优势。

Characteristics and regularity of somatosensory evoked potentials in patients with diabetic mild cognitive impairment

Objective To evaluate the status of cognitive function objectively by using the somatosensory evoked potential technology. Methods Recorded the relevant data of the somatosensory evoked potential test in the normal group, non-cognitive impairment group and MCI group, and 30 cases in each group. All data were analyzed statistically by SPSS 19.0 software. Results The results showed that the latent period of the peripheral nerve evoked potential and subcortical potential had no statistical significance in the three groups (P?>?0.05). The latent period of the cortical potential and the conduction time of central nerve in MCI group had statistical significance compared with the other two groups (P??0.05). Conclusion The research shows that the cortical potential of SEP was more sensitive to the evaluation of cognitive function and better than the scales. The cortical potential of SEP can be used to assess subclinical period in MCI. The cortex potential of the posterior tibial nerve had more advantages than the SEP of median nerve of subclinical stage and early evaluation of MCI.