Abstract: | We experienced a case of chronic hepatitis C showing spontaneous resolution. The patient was diagnosed as having chronic hepatitis with moderate activity, non-A non-B type, after laparoscopy with liver histology in 1982, and was followed up thereafter at our out-patient clinic. His aspartate aminotransferase (AST)and alanine aminotransferase (ALT) levels fluctuated but had stabilized by 1990. A second laparoscopy with liver histology, conducted in 1993, revealed non-specific reactive hepatitis. Serum hepatitis C virus RNA (HCV-RNA) had been strongly positive in 1982 but was negative in 1990. Interferon therapy may not be indicated in such cases. |