NET、WBC和CRP在口腔颌面部多间隙感染中的变化研究

摘要：目的  探讨中性粒细胞百分比（NET）、白细胞（WBC）和C-反应蛋白（CRP）在口腔颌面部多间隙感染患者血液中的动态变化及临床意义。方法  选取2012年1月-2016年3月在贵州省遵义市第一人民医院诊断为口腔颌面部多间隙感染患者100例作为病例组，同期选择100例健康体检人群作为对照组，比较两组血液中NET、WBC和CRP水平。结果  病例组治疗前、治疗后第1和3天的NET水平分别为（79.65±6.56）、（74.56±6.32）和（61.51±7.89）×109/L，CRP分别为（65.25±21.15）、（54.86±9.09）和（38.46±9.27）mg/L，WBC为（13.49±3.27）、（11.87±4.23）和（8.46±4.14）×109/L，均高于对照组，差异有统计学意义（P <0.05）。治疗后7 d的NET和WBC水平为（57.41±6.98）和（6.21±2.03）×109/L，与对照组比较，差异无统计学意义（P >0.05）。治疗后7 d的CRP水平为（12.38±3.78）mg/L，仍高于对照组，差异有统计学意义（P <0.05）；随着病情好转，NET、CRP和WBC水平均有改善，差异有统计学意义（P <0.05）。CRP在口腔颌面部多间隙感染中的敏感性（86.0%）高于NET（56.0%）和WBC（58.0%），差异有统计学意义（P <0.05）。结论  NET、CRP和WBC水平动态变化可以反映口腔颌面部多间隙感染患者病情变化，且CRP对病情发展有更高的敏感性。

Changes of NET, WBC and CRP in oral and maxillofacial multi-space infection

Abstract: Objective To study the dynamic changes of C-reactive protein (CRP), white blood cell (WBC) and neutrophile percentage (NET) in the patients with oral and maxillofacial multi-space infections and the significance. Methods This study included 100 patients with oral and maxillofacial multi-space infections (case group) and 100 healthy check-up people (control group) in our hospital from January 2012 to March 2016. The levels of NET, CRP and WBC were tested in the two groups. Results The NET, CRP and WBC levels before treatment and 1 d and 3 d after treatment in the case group were significantly higher than those in the control group (P < 0.05). There was no significant difference in NET or WBC 7 d after treatment between the case group and the control group (P > 0.05). The CRP level 7 d after treatment in the case group was significantly higher than that in the control group (P < 0.05). All the three indexes were improved with the improvement of the disease. The sensitivity of CRP in oral and maxillofacial multi-space infections was 86.0%, which was higher than 56.0% of NET and 58.0% of WBC. The difference were statistically significant (P < 0.05). Conclusions The dynamic changes of CRP, WBC and NET can reflect illness severity of oral and maxillofacial multi-space infections, among which CRP is more sensitive.