| 调节性B 细胞在吉兰- 巴雷综合征患者
外周血中的表达及意义 |
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| 引用本文： | 郝晨光,王艳,马建华.调节性B 细胞在吉兰- 巴雷综合征患者
外周血中的表达及意义[J].中国现代医学杂志,2020,30(4):34-38. |
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| 作者姓名： | 郝晨光 王艳 马建华 |
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| 作者单位： | [1. 新疆医科大学第一附属医院昌吉分院（昌吉市第二人民医院）神经内科，新疆 昌吉
831100 ；2. 新疆医科大学第一附属医院 神经内科，新疆 乌鲁木齐 830054] |
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| 基金项目： | 新疆维吾尔自治区自然科学基金（No ：2017D01A05） |
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| 摘 要： | 目的 研究吉兰- 巴雷综合征（GBS）患者外周血CD19+CD24hiCD38hiBreg、CD19+CD24hiCD27+
Breg 细胞的变化。方法 选取2018 年10 月—2019 年6 月新疆医科大学第一附属医院昌吉分院收治的GBS 患
者50 例作为GBS 组，选取同期该院健康体检者50 例作为对照组。检测两组外周血CD19+CD24hiCD38hiBreg、
CD19+CD24hiCD27+Breg 的表达。结果 GBS 组CD19+CD24hiCD38hiBreg 细胞表型比例较对照组低
（P <0.05）,GBS 组CD19+CD24hiCD27+Breg 细胞表型比例较对照组低（P <0.05）。结论 GBS 患者外周血
CD19+CD24hiCD38hiBreg、CD19+CD24hiCD27+Breg 细胞减少，其可能参与GBS 的发病，可作为疗效指标之一。
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| 关 键 词： | B 淋巴细胞 吉兰- 巴雷综合征/ 综合征 治疗结果 |
| 收稿时间： | 2019/8/23 0:00:00 |
Expression and significance of regulatory B cells in peripheral
blood of patients with Guillain-Barre syndrome |
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| Chen-guang Hao,Yan Wang,Jian-hua Ma.Expression and significance of regulatory B cells in peripheral
blood of patients with Guillain-Barre syndrome[J].China Journal of Modern Medicine,2020,30(4):34-38. |
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| Authors: | Chen-guang Hao Yan Wang Jian-hua Ma |
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| Institution: | (1. Department of Ineternal Neurology, Changji Branch of the First Hospital Affiliated to Xinjiang
Medical University, Changji, Xinjiang 831100, China; 2. Department of Ineternal Neurology, The
First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China) |
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| Abstract: | Objective To study the changes of CD19+CD24hiCD38hi Breg and CD19+CD24hiCD27+ Breg
cells in peripheral blood of patients with Guillain-Barre syndrome (GBS). Methods Flow cytometry was used to
detect the expression of CD19+CD24hiCD38hi Breg and CD19+CD24hiCD27+ Breg in peripheral blood of 50 patients
with Guillain-Barre syndrome and 50 healthy controls. Results The phenotype ratio of CD19+CD24hiCD38hi Breg
cells in GBS group was lower than that in control group (P < 0.05), and that of CD19+CD24hiCD27+ Breg cells in
GBS group was lower than that in control group (P < 0.05). Conclusion Decreased CD19+CD24hiCD38hi Breg and
CD19+CD24hiCD27+ Breg cells in peripheral blood of patients with GBS may be involved in the pathogenesis of
GBS,which may be an observation index of curative effect. |
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| Keywords: | b-lymphocytes Guillain-Barre syndrome/syndrome treatment outcome |
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