苓桂气化方对射血分数保留性心力衰竭模型大鼠心脏功能及糖脂代谢的影响

[目的]观察苓桂气化方(LGQH)对射血分数保留性心力衰竭(HFpEF)模型大鼠的心脏功能及血糖、血脂相关指标的影响.[方法]采用高脂高糖饮食诱导加低剂量链脲佐菌素(STZ)建立复合HFpEF心力衰竭大鼠模型,随机分为HFpEF模型组、诺欣妥组、苓桂气化方低剂量、高剂量组,以及自发性高血压大鼠(SHR)正常对照组、Wi...

Effects of Linggui Qihua Fang on cardiac function and glucose and lipid metabolism in rats with heart failure with preserved ejection fraction

[Objective] To observe the effects of Linggui Qihua Fang (LGQH) on cardiac function,blood glucose and blood lipid related indexes in rats with heart failure with preserved ejection fraction (HFpEF).[Methods] The composite HFpEF heart failure rat model induced by high fat and high sugar diet and low dose STZ was established. The rats were randomly divided into HFpEF model group,Nuoxintuo group,low-dose and high-dose groups of LGQH,SHR normal control group and WKY blank control group. Each administration group was given corresponding drugs,and the HFpEF model group and two control groups were given the same amount of normal saline for 8 weeks. The ultrasonic functional indexes of rat heart detected by echocardiography include mitral valve blood flow velocity (E) in early diastole and maximum mitral valve atrial systolic blood flow (A). Enzyme-linked immunosorbent assay (ELISA) was used to measure the contents of fasting insulin (FINS),C-peptide (C-P),atrial natriuretic peptide (ANP) and B-type brain natriuretic peptide (BNP). The cardiac tissues of rats were taken for gross pathology and pathological section detection.[Results] Compared with HFpEF group,Nuoxintuo and LGQH can improve E and E/A ratio to some extent (P<0.05 or P<0.01),LGQH group can reduce ANP and BNP content in rats in different degrees (P<0.05 or P<0.01),while the BNP content in Nuoxintuo group was lower than before (P<0.01). The contents of FINS,C-P and LEP in low-dose and high-dose groups of LGQH and Nuoxintuo group can be reduced in different degrees (P<0.05,P<0.01),and the levels of GSP and GLU in low-dose and high-dose groups of LGQH can also be reduced (P<0.05 or P<0.01). The levels of TC and LDL-CHO in low-dose and high-dose groups of LGQH were lower than before (P<0.05 or P<0.01). Nuoxintuo and low-dose and high-dose groups of LGQH can obviously improve the hs-CRP index of rats (P<0.01).[Conclusion] LGQH can improve the diastolic function of rat heart,inhibit atrial structural remodeling,reduce inflammatory factors,improve glucose and lipid metabolism and endothelial function.