| 中药单体治疗糖尿病视网膜病变的研究进展 |
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| 引用本文： | 秦魏,郭蒙,李欣雨,李奕衡,孙晓莹,靳洁,贾礼伊,曹慧玲.中药单体治疗糖尿病视网膜病变的研究进展[J].国际眼科杂志,2021,21(8):1373-1377. |
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| 作者姓名： | 秦魏 郭蒙 李欣雨 李奕衡 孙晓莹 靳洁 贾礼伊 曹慧玲 |
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| 作者单位： | 中国陕西省西安市,西安医学院基础与转化医学研究所 陕西省缺血性心血管疾病重点实验室,中国陕西省咸阳市,陕西中医药大学药学院,中国陕西省西安市,西安医学院基础与转化医学研究所 陕西省缺血性心血管疾病重点实验室,中国陕西省西安市,西北大学生命科学学院,中国陕西省咸阳市,陕西中医药大学药学院,中国陕西省咸阳市,陕西中医药大学药学院,中国陕西省咸阳市,陕西中医药大学药学院,中国陕西省西安市,西安医学院基础与转化医学研究所 陕西省缺血性心血管疾病重点实验室; 中国陕西省咸阳市,陕西中医药大学药学院; 中国陕西省西安市,西北大学生命科学学院 |
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| 基金项目： | 国家自然科学基金项目(No.U1932130); 陕西省科技厅重点研发一般项目(No.2021SF-303); 西安医学院配套基金项目(No.2018PT24); 西安医学院大学生创新创业训练计划项目(No.121521022) |
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| 摘 要： | 糖尿病视网膜病变(DR)是一种常见的糖尿病慢性并发症，可导致视网膜中微血管的不可逆性损伤，是糖尿病患者首要致盲性眼病。DR的发病机制主要涉及氧化应激、炎症反应与新生血管形成等因素。临床上多以视网膜激光光凝术、玻璃体切割术或药物治疗为主。我国传统中药组方与中药单体在DR治疗，特别是视网膜保护方面具有独特功效，为DR治疗提供有益补充。本文综述了代表性中药组方与中药单体在DR治疗中的应用实践与作用机制，以期为DR的临床治疗与新药研发提供参考。
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| 关 键 词： | 糖尿病视网膜病变 血管损伤 视网膜保护 中药组方 中药单体 |
| 收稿时间： | 2020/12/23 0:00:00 |
| 修稿时间： | 2021/7/8 0:00:00 |
Research progress of Chinese herb monomers in the treatment of diabetic retinopathy |
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| Wei Qin,Meng Guo,Xin-Yu Li,Yi-Heng Li,Xiao-Ying Sun,Jie Jin,Li-Yi Jia and Hui-Ling Cao.Research progress of Chinese herb monomers in the treatment of diabetic retinopathy[J].International Journal of Ophthalmology,2021,21(8):1373-1377. |
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| Authors: | Wei Qin Meng Guo Xin-Yu Li Yi-Heng Li Xiao-Ying Sun Jie Jin Li-Yi Jia and Hui-Ling Cao |
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| Affiliation: | Shaanxi Key Laboratory of Ischemic Cardiovascular Disease;Institute of Basic & Translational Medicine, Xi''an Medical University, Xi''an 710021, Shaanxi Province, China,College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China,Shaanxi Key Laboratory of Ischemic Cardiovascular Disease;Institute of Basic & Translational Medicine, Xi''an Medical University, Xi''an 710021, Shaanxi Province, China,College of Life Sciences, Northwest University, Xi''an 710069, Shaanxi Province, China,College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China,College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China,College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China and Shaanxi Key Laboratory of Ischemic Cardiovascular Disease;Institute of Basic & Translational Medicine, Xi''an Medical University, Xi''an 710021, Shaanxi Province, China; College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China; College of Life Sciences, Northwest University, Xi''an 710069, Shaanxi Province, China |
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| Abstract: | Diabetic retinopathy(DR)is a common chronic complication of diabetes mellitus, which cause irreversible damage of microvessels in the retina. DR is a leading blindness eye disease among diabetes mellitus. The pathogenesis of DR is mainly related to oxidative stress, inflammation and neovascularization. DR patients are treated with laser photocoagulation, vitrectomy and medicine in clinical trials. The traditional Chinese medicine and Chinese herb monomers have unique efficacy in the treatment of DR, especially in retinal protection, which provides valuable supplement. The paper summarized application practice and mechanism of representative Chinese herbal formulas and Chinese herb monomers in the treatment of DR, which would provide references for the clinical treatment and new drug development of DR. |
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| Keywords: | diabetic retinopathy vascular lesions retinal protection Chinese herbal formula Chinese herb monomer |
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