组织运动二尖瓣环位移技术评价糖尿病合并代谢综合征患者左心室收缩功能的临床研究

目的 采用超声组织运动二尖瓣环位移技术(TMAD)评价射血分数正常的2型糖尿病(T2DM)合并代谢综合征(MS)患者的左心室收缩功能.方法 收集左心室射血分数保留的T2DM患者(T2DM组)94例,根据是否合并MS,将T2DM组分为合并MS组(CMS组)与不合并MS组(NMS组),同期收集年龄、性别相匹配的50例志愿者...

Evaluation of left ventricular systolic function in patients with type2 diabetes mellitus with metabolic syndrome using tissue motiontracking of mitral annular displacement

Objective To evaluate left ventricular systolic function in patients with type 2 diabetes (T2DM)with preserved left ventricular ejection fraction (LVEF) using tissue mitral valve annulus displacement (TMAD) andthe effects of metabolic syndrome (MS) on left ventricular systolic function in patients with T2DM. Methods Atotal of 94 T2DM patients with preserved LVEF were collected as the case group. According to whether the patientswere combined with MS, the T2DM patients were divided into the combined MS group (CMS group) and the noncombinedMS group (NMS group), and 50 healthy people with matching age and sex were collected during the sameperiod as control group. Echocardiography was used to measure conventional parameters such as left ventriculardiastolic volume (LVEDV), LVEF, and mitral velocity, and we used two-dimensional speckle trackingechocardiography to measure TMAD parameters such as mitral annulus septal site displacement (TMAD1), lateral site displacement (TMAD2), average The displacement (TMADmid), and the average displacement rate(TMADmid%). Then, we compared the differences of parameters between each group. Results The comparison ofthe results of conventional echocardiography parameters between the T2DM group and the control group wasstatistically significant (P < 0.05); compared with the control group, the LVEDV of T2DM patients was increased,and the Mitral E/A was decreased (P < 0.05), and there was no significant difference in LVEF between the groups(P > 0.05). The comparisons of the TMAD parameter results among the control group, CMS group, and NMS groupwere statistically significant (P < 0.05); compared with the control group, the TMAD parameters (including TMAD1,TMAD2, TMADmid, TMADmid%) of patients in the CMS group and NMS group were reduced (P < 0.05), and theTMAD parameters of the patients in the CMS group were lower than those in the NMS group (P < 0.05).Conclusions Left ventricular systolic function in patients with T2DM with LVEF preserved still decreases, and thedecrease of the left ventricular systolic function in T2DM patients with MS is more significant. The TMADparameter can be used as a new parameter for clinical evaluation of left ventricular systolic function, and has theadvantages in simple operation, accuracy, and sensitivity.