FRY蛋白在不同恶性程度乳腺肿瘤中的表达与意义

目的  研究不同恶性程度的乳腺肿瘤病例中FRY蛋白的表达情况及其与临床病理参数之间的关系。方法  对收集的104例乳腺肿瘤病例（其中纤维囊性乳腺病11例，不同分级的乳腺浸润性导管癌93例）中FRY蛋白的表达情况进行免疫组织化学检测，比较FRY蛋白表达情况与乳腺肿瘤恶性程度及不同临床病理参数之间的关系。结果  11例纤维囊性乳腺病与93例乳腺浸润性导管癌病例中FRY蛋白表达阳性率分别为90.9%和54.8%，差异有统计学意义（P <0.05）；93例乳腺癌病例中，FRY蛋白在乳腺癌不同组织分级、不同TNM分期、肿瘤直径大小、PR水平间的表达均有显著性差异（P <0.05）。结论  FRY蛋白的表达与乳腺肿瘤的恶性程度相关，恶性程度越高，FRY蛋白表达越少，同时FRY蛋白的表达与体内激素受体水平也存在一定联系。

Expression of FRY and its significance in breast carcinomas with different degree of malignancy

Objective To study the expression level of FRY protein in breast carcinomas of various degree of malignancy and its relationship with clinical pathological parameters. Methods One hundred and four cases of breast carcinomas were studied using immunohistochemical method, among which 11 cases had fibrocystic breast disease and 93 cases had invasive ductal carcinomas of breast. The expression level of FRY protein was determined, and the possible relationships between the FRY expression and a number of clinical pathological parameters were investigated. Results There was a significant difference in the positive rate of FRY expression between the fibrocystic breast disease cases and the breast invasive ductal carcinoma cases (90.9% vs 54.8%, P < 0.05). In the breast invasive ductal carcinomas, FRY expression was positively correlated with histological grades, TNM stages, tumor diameter and PR expression (P < 0.05). Conclusions The expression of FRY protein is strongly correlated with the malignant degree of breast carcinomas; the higher the malignancy of the carcinomas, the lower the expression level of FRY protein. Meanwhile, FRY expression is also related to progesterone receptor level in the body.