那他霉素联合伊曲康唑治疗真菌性角膜炎的疗效分析

目的观察那他霉素滴眼液联合伊曲康唑胶囊治疗真菌性角膜炎的临床疗效。方法选取2014 年3月-2016年5月浙江省宁波市眼科医院收治的真菌性角膜炎患者92 例，随机分为观察组（那他霉素滴眼液+伊曲康唑胶囊）和对照组（那他霉素滴眼液），两组患者治疗14 d 后对比临床疗效、治疗前后角膜染色、共聚焦角膜显微镜等，并记录与治疗相关不良反应发生情况。结果观察组临床治疗总有效率为86.96%、对照组为63.04%，观察组高于对照组（p <0.05）。观察组治疗后角膜染色阳性率为13.04%、对照组为36.96%，观察组低于对照组（p <0.05）。结论对于真菌性角膜炎患者在局部使用那他霉素滴眼液基础上，配合口服伊曲唑康胶囊能够提高临床疗效，用药方便，值得临床推广应用。

Efficacy of Natamycin eye drops and Itraconazole in treatment of fungal keratitis

Objective To observe clinical efficacy of Natamycin eye drops combined with Itraconazole capsules in the treatment of fungal keratitis. Methods Ninety-two patients with fungal keratitis treated in our hospital from March 2014 to May 2016 were randomly divided into observation group (Natamycin eye drops and Itraconazole capsules) and control group (Natamycin eye drops). After 14 days of treatment, the clinical efficacy, fluorescein sodium staining of cornea before and after treatment, and the incidences of adverse reactions were recorded. Results The total effective rate was 86.96% in the observation group which was significantly higher than 63.04% in the control group (p < 0.05). The positive rate of corneal staining was 13.04% in the observation group, and 36.96% in the control group, the difference was significant (p < 0.05). Conclusions For the patients with fungal keratitis, oral administration of Itraconazole capsules on the basis of Natamycin eye drops can improve clinical efficacy, while medication convenience and safety are guaranteed. It is worthy of clinical application.