| 铅中毒和驱铅药物的研究进展 |
| |
| 引用本文： | 何剪太,朱轩仪,巫放明,肖平.铅中毒和驱铅药物的研究进展[J].中国现代医学杂志,2017,27(14):53-57. |
| |
| 作者姓名： | 何剪太 朱轩仪 巫放明 肖平 |
| |
| 作者单位： | 1.中南大学湘雅医院普外科；2.中南大学湘雅医院国家卫生和计划生育委员会纳米生物技术重点实验室；
3.中南大学湘雅医院肾内科，湖南长沙410008 |
| |
| 基金项目： | 国际合作项目（No：2013DFA31440） |
| |
| 摘 要： | 铅中毒是一种铅暴露引起的直接损害神经系统并累及多种器官的疾病。由于铅在日常生活中应用广泛，铅中毒已经成为一种常见疾病。本研究就铅中毒及其对神经、造血、骨骼、生殖系统及肾脏损伤做综述，并描述应用于驱铅药物研究的细胞和动物模型以及阐述常用驱铅药物的利弊，重点介绍了通过阻断肝肠循环治疗铅中毒的研究。
|
| 关 键 词： | 铅中毒 驱铅药物 肝胆循环 细胞模型 动物模型 |
| 收稿时间： | 2017/4/28 0:00:00 |
Research progress on lead poisoning and development of deleading reagents |
| |
| Jian-tai He,Xuan-yi Zhu,Fang-ming Wu,Ping Xiao.Research progress on lead poisoning and development of deleading reagents[J].China Journal of Modern Medicine,2017,27(14):53-57. |
| |
| Authors: | Jian-tai He Xuan-yi Zhu Fang-ming Wu Ping Xiao |
| |
| Institution: | 1. Department of General Surgery, 2. Key Laboratory of Nanobiotechnology of National Health
and Family Planning Commission, 3. Department of Nephrology, Xiangya Hospital of
Central South University, Changsha, Hunan 410008, China |
| |
| Abstract: | Lead poisoning is a disease caused by lead exposure which can directly damage the nervous system and other organs. Since lead is widely used in daily life, lead poisoning has become a common disease. This paper reviews lead poisoning and its damages in the nerve system, hematopoietic system, skeletal system, reproductive system and kidneys, also describes some cell and animal models of lead poisoning for deleading drug research, and explains the advantages and disadvantages of the commonly-used deleading drugs. Importantly, this review introduces a new concept of therapeutics of lead poisoning by blocking the enterohepatic circulation. |
| |
| Keywords: | lead poisoning deleading drug enterohepatic circulation cell model animal model |
|
| 点击此处可从《中国现代医学杂志》浏览原始摘要信息 |
| 点击此处可从《中国现代医学杂志》下载免费的PDF全文 |
|
