同型半胱氨酸血症、胰岛素抵抗和超敏C- 反应蛋白与高血压前期相关性分析

目的 评价高血压前期患者血清同型半胱氨酸、胰岛素抵抗和高敏C 反应蛋白水平及其相关性。方法 根据联合委员会第七次关于高血压预防、检测、评价和治疗报告指南，募集60 例高血压前期患者和32 例血压正常志愿者。分析所有受试者血清同型半胱氨酸、维生素B12、叶酸、胰岛素、高敏C 反应蛋白和脂质含量。独立t 检验比较两组参数差异，皮尔逊相关系数分析两组患者参数与舒张压和收缩压的相关性。结果 高血压前期组受试者血清同型半胱氨酸、胰岛素抵抗和炎症标记物高敏C 反应蛋白等心血管危险因素高于血液正常志愿者。高血压前期组受试者总胆固醇、三酰甘油、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇也较血压正常志愿者者高。血清同型半胱氨酸与收缩压呈正相关，维生素B12 和叶酸与收缩压呈负相关。结论 高同型半胱氨酸血、胰岛素抵抗和血清hs-CRP 水平升高与高血压前期相关，并且可以增加受试者心血管疾病发生风险

Correlation analysis of hyperhomocysteinemia, insulin resistance and hypersensitivity C-reactive protein with prehypertension

Objectives To evaluate the correlation of hyperhomocysteinemia, insulin resistance and hypersensitivity C-reactive protein (hs-CRP) with prehypertension. Methods Sixty prehypertensives and 32 normotensives were recruited according to Seventh Report of the Joint National Committee on Prevention,Detection, Evaluation and Treatment of blood pressure (JNC 7) guidelines. Serum homocysteine, vitamin B12, folate,insulin, hs-CRP and lipid profile were analyzed. Independent t-test was carried out in the two groups and Pearson correlation analyses were carried out between various parameters and systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively. Results Cardiovascular risk factors like serum homocysteine, insulin resistance and inflammatory marker hs-CRP were significantly increased in prehypertensives. Total cholesterol, TG, LDL-C and VLDL-C were significantly increased in prehypertensives compared with those in normotensives. Serum homocysteine correlated positively with SBP while vitamin B12 and folate correlated negatively with it. Conclusion Homocysteine, insulin resistance, and hs-CRP have correlation with prehypertension and can increase the risk of cardiovascular disease in the subjects.