| 硒结合蛋白 1 抗肿瘤作用研究进展 |
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| 引用本文： | 曾谷清,谭杏,廖力.硒结合蛋白 1 抗肿瘤作用研究进展[J].中国现代医学杂志,2017,27(10):62-65. |
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| 作者姓名： | 曾谷清 谭杏 廖力 |
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| 作者单位： | 南华大学护理学院，湖南，衡阳 421001 |
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| 基金项目： | 国家自然科学基金（No：81470130；81272959）；南华大学博士科研启动基金（No：2013XQD33）；南华大学研究生科研创新项目
(No：2016XCX41) |
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| 摘 要： | 硒结合蛋白 1 是一种含硒蛋白质，它与硒共价结合，参与了晚期高尔基体内蛋白质的转运。大量研究表明硒结合蛋白 1 是一种新型的抗肿瘤物质，与肿瘤细胞的增殖、分化和凋亡等密切相关。本文旨在探讨硒结合蛋白 1 与肿瘤的发生与发展、分化程度、增殖、凋亡、转移、化疗敏感性和预后的关系，以期为肿瘤的早期诊断与个体化治疗提供指导，改善肿瘤患者的预后。
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| 关 键 词： | 硒结合蛋白 1 抗肿瘤 细胞增殖 化疗敏感性 预后 |
| 收稿时间： | 2016/12/25 0:00:00 |
Research progress on antitumor effect of selenium binding protein 1 |
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| Gu-qing Zeng,Xing Tan,Li Liao.Research progress on antitumor effect of selenium binding protein 1[J].China Journal of Modern Medicine,2017,27(10):62-65. |
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| Authors: | Gu-qing Zeng Xing Tan Li Liao |
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| Institution: | School of Nursing,University of South China,Hengyang,Hunan 421001,China |
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| Abstract: | Selenium binding protein 1 (SBP1)is a member of selenoprotein family,hasbeen shown to covalently
bind selenium and participate in the transportation ofproteinsin Golgibody.Many studiesshowed thatSBP1 is a novel tumor suppressor protein closely related to tumor cell proliferation,differentiation and apoptosis.The aim of thispaperisto investigate thecorrelations between selenium binding protein 1 and tumoroccurrence,development,differentiation,proliferation,apoptosis,metastasis,chemotherapy sensitivity and prognosis,so asto provide a scien-tific guidance for early diagnosis and individualized therapy of tumors,improve the prognosis of tumor patients. |
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| Keywords: | selenium binding protein l antitumor cell proliferation chemotherapy sensitivity prognosis |
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