核因子E2相关因子2在肺腺癌中的表达及临床意义

目的  研究核因子E2相关因子2（以下简称转录因子Nrf2）在肺腺癌组织中的表达及临床意义。方法  收集本院胸外科手术治疗的肺腺癌组织标本88例，正常肺组织标本20例，应用免疫组织化学法，检测组织标本中Nrf2的表达水平。结果  Nrf2在正常肺组织中阳性表达率低于10%，在肺腺癌组织中的阳性表达率为69.3%，在有淋巴结转移的肺腺癌组织中Nrf2的阳性表达率为73.3%。低分化组腺癌组Nrf2阳性表达率（84.6%）明显高于中分化组（76.4%）和高分化组（70.7%）。结论  转录因子Nrf2在肺腺癌组织中表达上调，与肺腺癌的组织分化程度、淋巴转移具有一定的相关性。

Expression and clinical significance of Nrf2 in pulmonary adenocarcinoma

Objective To study the expression and clinical significance of signal molecule Nrf2 in pulmonary adenocarcinoma tissues. Methods 88 tissue samples of pulmonary adenocarcinoma and 20 normal lung tissues were collected as research subject. The expressions of Nrf2 in lung tissues were identified by immune histochemistry. Results The positive expression rate of Nrf2 was less than 10 % in normal lung tissue, while it was 69.3 % in tissue samples of pulmonary adenocarcinoma, and 73.3 % in samples combined with metastasis of lymph nodes. The positive expression rate of Nrf2 was higher in poorly differentiated group (84.6 %) than that in middle (76.4 %) and high differentiation group (70.7 %). Conclusion The expression of Nrf2 was upregulated in tissues of pulmonary adnocarcinoma, and it was related with the degree of differentiation and lymph node metastasis of lung adenocarcinoma.