酪酸梭菌联合四联疗法治疗幽门螺杆菌阳性胃溃疡的作用机制研究

摘要：目的  观察酪酸梭菌（Cb）联合四联疗法治疗幽门螺杆菌（Hp）阳性胃溃疡的作用。方法  选取Hp阳性胃溃疡102例，采取随机双盲方法，将其分为观察组和对照组。前2周，观察组口服埃索美拉唑镁肠溶片+枸橼酸铋剂钾片+阿莫西林胶囊+左氧氟沙星片+酪酸梭菌活菌胶囊，对照组在上述四联疗法基础上加空白胶囊；后2周，停用抗生素和枸橼酸铋剂钾片。疗程结束后1个月，比较两组治疗有效率、Hp根除率、不良反应发生率。结果  观察组有效率为89.46%，对照组为76.00%，经χ2检验，差异无统计学意义（P >0.05）。观察组HP根除率为82.69%，对照组HP为64.00%，经χ2检验，差异有统计学意义（P <0.05）。观察组不良反应发生率为11.54%，对照组为18.00%，经χ2检验，差异无统计学意义（P >0.05）。结论  Cb联合四联疗法能够提高胃溃疡Hp根除率。

Effect of Clostridium butyricum combined with quadruple therapy on Helicobacter pylori-positive gastric ulcer

Abstract: Objective To observe the effect of Clostridium butyricum joint quadruple therapy on Helicobacter pylori-positive gastric ulcer. Methods A total of 102 cases with H. pylori-positive gastric ulcer were selected. Adapting randomized double-blind method, they were divided into observation group and control group. In the first 2 weeks, the patients in the observation group were treated with a quadruple therapy (Esomeprazole + Bismuth Potassium Citrate + Amoxicillin + Levofloxacin) combined with Clostridium capsules; while those in the control group received the same quadruple therapy plus blank capsules. After 2 weeks, bismuth potassium citrate  and antibiotics were stopped. The treatment efficiency, H. pylori eradication rate, and incidence of adverse reactions were compared between the two groups 1 month after treatment. Results The effective percentage was 89.46% in the observation group and 76.00% in the control group, the difference was not statistically significant (P > 0.05). The eradication rate of H. pylori was 82.69% in the observation group, while 46.00% in the control group, the difference was statistically significant (P < 0.05). The incidence of adverse reactions was 11.54% in the observation group and 18.00% in the control group, the difference was not statistically significant (P > 0.05). Conclusions Clostridium combined with quadruple therapy can increase the eradication rate of H. pylori in gastric ulcer.