青海地区胃癌发病危险因素的病例对照研究

目的 分析青海地区胃癌发病的危险因素和保护因素,为该地区胃癌的一级预防提供科学依据.方法 选取2014年9月—2018年6月于青海省人民医院肿瘤内科住院并经病理活检明确诊断为胃癌的患者389例作为病例组.选取同期该院健康体检者作为对照组.采用单因素及多因素Logistic回归分析胃癌发病的危险因素和保护因素.结果 单因...

A case-control study on risk factors of gastric cancerin Qinghai area*

Objective To analyze the risk factors and protective factors of gastric cancer in Qinghai area, andto provide evidence for primary prevention of gastric cancer in this area. Methods We enrolled 389 gastric cancerpatients with pathological diagnosis hospitalized in the Department of Medical Oncology of Qinghai ProvincialPeople''s Hospital from September 2014 to June 2018. Another 389 healthy physical examinees in our hospital at thesame period were selected as control group. Univariate and multivariate conditional Logistic regression analysis wasperformed using SPSS 20.0 statistical software. Results Univariate analysis found that occupation, educationaldegree, economic income, history of chronic esophagitis, history of gastritis, history of gastric ulcer, history ofgastric bleeding, history of gastric polyp, history of hepatitis, history of cholecystitis/cholelithiasis, Helicobacter pylori infection, smoking, alcohol consumption, drinking tea , greasy diet, fast eating, salt-heavy diet, often eatingpickled food, fried food, and ghee, regular diet, eating fresh vegetables and fruits, drinking tap water, family historyof cancer, heavy pressure of work, and short-tempered personality were either risk factors or protective factors forgastric cancer (P < 0.05). Furthermore, multivariate Logistic regression analysis indicated that esophagitis [O^R =13.692, (95% CI: 1.573, 119.162)], gastritis [O^R = 6.005, (95% CI: 1.812, 19.894)], gastric ulcer [O^R = 23.623(95% CI: 3.595, 155.245)], cholecystitis/cholelithiasis [O^R = 6.465 (95% CI: 1.191, 35.089)], Helicobacter pyloriinfection [ O^R = 18.712 (95% CI: 5.041, 69.451)], smoking [ O^R = 5.174 (95% CI: 2.092, 12.797)], alcoholconsumption [O^R =9.030 (95% CI: 3.725, 21.892)], greasy diet [O^R = 3.068 (95% CI: 1.338, 7.0360)], fast eating[O^R = 5.349 (95% CI: 2.412, 11.866)], salt-heavy diet [O^R = 2.825, (95% CI: 1.321, 6.041)], and often eatingpickled food [O^R = 2.643 (95% CI: 1.081, 6.459)] were risk factors for gastric cancer, and that non-peasant and nonherdsman[O^R = 0.260 (95% CI: 0.112, 0.602)], high educational degree [O^R = 0.084 (95% CI: 0.033, 0.216)], higheconomic income [O^R =0.179 (95% CI: 0.075, 0.430)], regular diet [O^R = 0.246 (95% CI: 0.740, 0.826)], eatingfresh vegetables [O^R =0.199 (95% CI: 0.087, 0.452)] and drinking tap water [O^R = 0.042 (95% CI: 0.009, 0.185)]were protective factors for gastric cancer. Conclusions The high incidence of gastric cancer in Qinghai area may berelated to poor living and eating habits and history of chronic gastropathy. It is recommended to develop scientificpreventive measures for intervention of the relevant factors.