Nasal human calcitonin for tumor-induced hypercalcemia |
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Authors: | J. C. Dumon A. Magritte J. J. Body |
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Affiliation: | (1) Department of Medicine and Laboratory of Endocrinology and Breast Cancer Research (Bone Metabolism Unit), Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Rue Héger-Bordet 1, B-1000 Brussels, Belgium |
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Abstract: | Summary We treated four hypercalcemic cancer patients by nasal hCT, 3×2 mg daily, which has been reported to be active in Paget's disease at lower doses. Only one patient became normocalcemic and mean (± SEM) calcium levels fell from 11.6±0.2 mg/dl before therapy to 10.7±0.6 mg/dl 2–3 days after starting hCT. The tolerance was excellent but, because of insufficient efficacy, we do not recommend this form of therapy for cancer hypercalcemia. |
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Keywords: | Hypercalcemia Calcitonin Cancer Bone resorption |
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