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Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies |
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| Authors: | Dennis O Mook-Kanamori Sandra WK de Kort Cornelia M van Duijn Andre G Uitterlinden Albert Hofman Henri?tte A Moll Eric AP Steegers Anita CS Hokken-Koelega Vincent WV Jaddoe |
| Affiliation: | (1) The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands;(2) Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands;(3) Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands;(4) Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands;(5) Department of Obstetrics & Gynecology, Erasmus Medical Center, Rotterdam, the Netherlands |
| Abstract: | BackgroundAn inverse association between birth weight and the risk of developing type 2 diabetes (T2D) in adulthood has been reported. This association may be explained by common genetic variants related to insulin secretion and resistance, since insulin is the most important growth factor in fetal life. The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy. |
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