Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer |
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| Authors: | Shahab Uddin Rong Bu Maqbool Ahmed Jehad Abubaker Fouad Al-Dayel Prashant Bavi Khawla S Al-Kuraya |
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| Affiliation: | (1) Department of Human Cancer Genomic Research, Research Center, Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia |
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| Abstract: | Background Recent epidemiological studies have suggested that obesity is associated with ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor development by enhancing cell growth and survival. This study was design to investigate the prevalence of leptin and Ob-R in Middle Eastern epithelial ovarian cancer (EOC) and to analyze the role of leptin and the mechanisms under its action in EOC tissue sample and cell lines. |
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