肾小管性酸中毒148例临床分析

目的探讨肾小管性酸中毒(RTA)的病因、分型、临床特点,以助早期诊断及治疗,减少严重并发症的发生。方法回顾性分析148例RTA患者的临床资料。结果病因原发性RTA占34.5%、继发性RTA占65.5%;临床分型Ⅰ型占77.0%、Ⅱ型占9.5%、Ⅲ型占11.5%,Ⅳ型占2.0%。女性RTA病因以原发性干燥综合征多见(27.5%);成人RTA最常见的临床表现为肌无力(75.5%),儿童以生长发育落后多见(57.1%)。结论 RTA临床表现多样,多种疾病可以继发RTA,临床医生要提高对RTA的认识;RTA伴生长发育落后的儿童使用生长激素追赶生长治疗值得重视。

Clinical analysis of 148 cases with renal tubular acidosis

Objective To discuss the cause,types and clinical manifestations of renal tubular acidosis and to reduce its severe complications.Methods Review analysis of 148 RTA patient’s clinical material had been made.Results About 34.5% of patients had primary RTA,secondary RTA account for 65.5%;among which Type I account for 77.0%,TypeⅡaccount for 9.5%,Type Ⅲ account for 11.5% and Type IV account for 2.0% respectively.The main cause of RTA in female was primary sjogren’s syndrome(27.5%).The main clinical manifestation of RTA was muscle weakness(75.5%)in adults and growth retardation in children(57.1%).Conclusions RTA has diverse clinical manifestations.Many diseases can cause RTA,Clinician must enhance their understanding about RTA and in RTA patients associated with growth retardation,the use of growth hormone to catch up growth is worth taking.