Granisetron prevents nausea and vomiting during spinal anaesthesia for caesarean section |
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Authors: | Y Fujii H Tanaka H Toyooka |
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Institution: | Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki;Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan |
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Abstract: | Background: Nausea and vomiting during spinal anaesthesia for caesarean section are common and unpleasant complications. This study was undertaken to evaluate the efficacy of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, for prophylactic treatment of nausea and vomiting in parturients undergoing nonemergent caesarean section under spinal anaesthesia. Methods: In a randomized, double-blind, placebo-controlled trial, 100 patients, 21–38 years, received either placebo (saline) or granisetron at 3 different doses (20 μg · kg-1, 40 μg · kg-1 or 80 μg · kg-1) (n=25 for each) intravenously immediately after clamping of the foetal umbilical cord. Nausea, vomiting and safety assessments were performed during spinal anaesthesia for caesarean section. Results: The treatment groups were similar with regard to maternal characteristics and operative management. The incidence of nausea and vomiting was 64%, 52%, 14% and 12% after administration of placebo and granisetron in a dose of 20 μg · kg-1, 40 μg · kg-1 and 80 μg · kg-1, respectively ( P <0.05; overall Fisher's exact probability test). No clinically important adverse effects were observed in any group. Conclusions: Prophylactic use of granisetron in a minimum dose of 40 μg · kg-1 is effective for preventing nausea and vomiting during spinal anaesthesia for caesarean section. © Acta Anaesthesiologiat Scandinavica 42 (1998) |
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Keywords: | Complications nausea vomiting vomiting antiemetics granisetron anesthesia obstetric |
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