猪复合皮移植的实验研究

目的：为使复合皮移植的动物实验结果进一步接近临床，用小香猪作动物模型，探讨复合皮移植的术后效果和成活机制。方法：实验分3组，A组为移植异体普通乳猪真皮+成年小香猪自体表皮皮片；B组为移植异体成年小香猪真皮+成年小香猪自体表皮皮片；C组为移植成年小香猪自体表皮皮片。术后观察3组皮片的存活质量及组织学变化。结果：3组皮片早期成活情况均较好，A组和B组晚期收缩率及瘢痕程度均比C组低。A组和B组的组织学结构较完整，异体普通乳猪真皮的成活情况优于异体成年小香猪真皮。结论：异体真皮的存在能改进复合皮移植的质量，而且以含异体普通乳猪真皮组成的复合皮效果最佳。

EXperimental study about the grafting of composite skin on swine

Aim: Swine were used as animal models for composite skin to make their experimental results close to clinic, andto explore their survival mechanism and results after the operations. Methods:Three groups were designed:in group A, allogenicdermis of new-borne swine and autologous epidermis grafts were transplanted; but in group B, the allogenic dermis of adult swineand autologous epidermis graft; in group C, only the autologous epidermis graft. After the operations, the grafts were observed andtissue was obtained for histological study. Restults: The survival status in 3 groups were satisfied in early time. The contractiverate and scar forming in group A and group B were lower than those in group C. There was much integral histological structure ingroup A and group B than that in group C, and the survival status in allogenic dermis of new-borne swine was better than that inallogenic dermis of adult swine. C onclusion:Allogenic dermis can improve the composite skin's quality, furthermore, the com-posite skin having allogenic dermis of sucking swine has the best result.