119例重症药疹的回顾性分析

目的：探讨重症药疹的临床特点、常见致敏药物及治疗，为临床安全用药，减少重症药疹发生提供参考。方法：对华山医院2006年1月-2012年12月收治的119例重症药疹患者的临床资料进行回顾性分析。结果：致敏药物类别以抗菌药物最多见（43例，30．1％），最易引起重症药疹的两种药物为卡马西平（32例，26．9％）和别嘌呤醇（23例，19．3％）；药疹类型中，重症多形性红斑型为最常见的重症药疹；中毒性表皮坏死松解型为最凶险的类型，死亡2例，死因均为呼吸衰竭。结论：对易致重症药疹的药物临床使用中应加强药学监护，发现异常及时停药，并早期、足量使用糖皮质激素，控制并发症的发生。

Retrospective analysis of 119 cases with severe drug eruption

AIM. To investigate the common sensitize medicines and prevention of severe drug eruption and appreciate causal link between the drug and the reaction. METHODS： A retrospec- tive study over a period of 7 years （January 2006 to December 2012） was carried out in the hospi- tal to record severe cutaneous ADRs of 119 hos- pitalized patients. RESULTS：Antibacterials were the most common causative drugs （43,30.1%）. Carbamazepine（32,26.9 %） and allopurinol （23, 19.3%） were the commonest initiating drugs. SJS accounted for the highest proportion, TEN accounted for the most dangerous. Two casesdied of respiratory failure. CONCLUSION. Prone to cause severe drug eruption drug, strengthe- ning pharmaceutical care during clinical use. ab- normal timely withdrawal and giving sufficient corticosteroids treatment early to control the in- cidence of complications.