内源性大麻素系统与老年性痴呆

老年性痴呆即阿尔茨海默病（Alzheimer’Sdisease，AD）是一种慢性进行性的神经退行性病变，其特征性病理改变为β-淀粉样蛋白（β-amy-loidpeptide，Aβ）沉积形成的细胞外老年斑和tau蛋白过度磷酸化形成的神经细胞内神经原纤维缠结，以及神经元丢失伴随胶质细胞增生等。最近的研究发现内源性大麻素系统对AD的病程有预防治疗作用，主要基于其对神经的保护作用和抗炎功效。本文综述了内源性大麻素对AD的保护作用的几个方面，旨在为AD的治疗开辟新的策略和思路。

Endogenous cannabinoid system and Alzheimer Disease

Alzheimer＇ s disease （AD） is a chronic progressing neurodegenerative disorder, and the principal neuropathological hallmark of the disease, is the extracellular ~-amyloid pep- tide（Aβ） accurnu- lation formed senile plaques, intracellular hyperphosphorylated tau formed neurofibrillary tangles, and loss of neuron with gliocyte proliferation. Recent evidence shows that endogenous cannabinoid system serve as preventive treatment for AD, based on theirneuroprotective and anti-inflammatory effects. Here we summarizes several aspects of the en- dogenous cannahinoid protective effect of the AD, aiming at providing a new method for the treatment of AD.