| 肝素酶在肿瘤侵袭转移中的作用及其机制 |
| |
| 引用本文： | 聂宸麟,陈晓鹏.肝素酶在肿瘤侵袭转移中的作用及其机制[J].中国临床药理学与治疗学,2014(7):812-817. |
| |
| 作者姓名： | 聂宸麟 陈晓鹏 |
| |
| 作者单位： | 皖南医学院弋矶山医院肝胆一科,安徽芜湖241001 |
| |
| 基金项目： | 国家自然科学基金资助项目（81272412） |
| |
| 摘 要： | 肝素酶（HPSE）是一种糖苷内切酶，能特异性水解位于细胞表面、细胞外基质及基底膜的硫酸乙酰肝素。肝素酶可促进肿瘤浸润、转移和血管生成，并参与免疫监视、胚胎植入等病理生理过程。本文对HPSE促进肿瘤转移的相关机制和肝素酶抑制剂的相关研究进展进行综述。过程。本文对HPSE促进肿瘤转移的相关机制和肝素酶抑制剂的相关研究进展进行综述。
|
| 关 键 词： | 肝素酶 肿瘤转移 抑制剂 |
Role of heparanase in the invasion and metastasis of tumor and its mechanism |
| |
| NIE Chen-lin,CHEN Xiao-peng.Role of heparanase in the invasion and metastasis of tumor and its mechanism[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2014(7):812-817. |
| |
| Authors: | NIE Chen-lin CHEN Xiao-peng |
| |
| Institution: | Department of General Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241001 ,An hui, China |
| |
| Abstract: | Heparanase （HPSE） is heparan sulfate-degrading enzymes, which could specific- ally degrade the heparan sulfate proteoglycans associated with the cell surface, extracellular matrix and basement membrane. It can promote tumor invasion, metastasis and angiogenesis, moreover participate in the process of patho- physiological as immunological surveillance andembryo impantation. This review will summer ize the role of HPSE in facilitating tumor meta static and the advance in its inhibitor. |
| |
| Keywords: | heparanase tumor metastasis angiogenesis |
| 本文献已被 维普 等数据库收录！ |
