4a间鲍曼不动杆菌临床分析特点及耐药变迁

目的:了解本地区鲍曼不动杆菌对常用抗生素的耐药变迁及临床分布情况,为有效的临床治疗和医院感染控制提供实验室依据。方法:采用回顾性调查方法,对2001至2004年间,临床分离的鲍曼不动杆菌的耐药率及临床分布情况进行统计分析。结果:283株鲍曼不动杆菌78.1%分离自呼吸道标本,77.7%来源于内科病区,感染患者60岁以上的占59.4%。对14种常用抗生素的耐药率总体呈上升趋势,上升幅度最大的为头孢噻肟。到2004年,庆大霉素、哌拉西林、头孢噻肟、头孢他啶、头孢三嗪、环丙沙星和复方新诺明的耐药率均大于50%;介于30%~40%的有阿米卡星、妥布霉素、氨苄西林/舒巴坦、氨曲南、头孢吡肟;亚胺培南的耐药率最低,为1.1%,其次为哌拉西林/他唑巴坦,为27.5%。此外,多重耐药菌株检出率由23.5%递增至59.3%。结论:动态监测鲍曼不动杆菌的临床分布特点和耐药谱变化,有助于指导临床制定最佳的感染控制措施和经验治疗方案,对减缓细菌耐药性的发展具有积极的意义。

Analysis on Drug Resistance Changes and Clinical Distribution of Acinetobacter Baumannii Durmg Past Four Years

Objective To investigate the drug resistance changes and clinical distribution of Actinetobacter baumannii(Ab).Methods Drug resistance and clinical distribution of Ab during 2001 to 2004 were analysed and studied retrospectively.Results The most common in fective site wasrespiratory tract and the risk area was ICU.There was a elevated tendency of resistance rates to 14 common antibiotics during past 4 years,especiflly cefotaxime.The resistance rates of most antibiotics were more than 50% in 2004,but still highly sensitive to imipenem.The multires istant Ab in clinic hadascending tendency.Conclusion To prevent infection outbreak,it is very important to monitor drug resistant changes of Ab constantly and regularly.