妊娠急性脂肪肝组织的体液免疫反应

目的:观察妊娠急性脂肪肝(AFLP)发病有无体液免疫反应参与.方法:采用免疫组化染色方法,观察3例AFLP肝组织中各种免疫球蛋白和补体的沉积.结果:例1,2肝小叶的肝血窦内皮细胞上均有大量IgG、C1q或C4c粗颗粒状沉积,血窦内枯否氏细胞吞噬IgG、IgM、IgA及C1q阳性颗粒,汇管区有不等量C1q沉积和血管内皮细胞C4d.例3肝血窦内皮细胞和汇管区有较多IgG、IgM、IgA沉积,但补体沉积很少.结论:AFLP肝脏组织中存在不同程度的体液免疫反应,可能是其重要的发病因素.

Humoral immunity reactions in the liver tissues of patients with acute fatty liver during pregnancy

AIM:To observe whether humoral immunity reactions participate in acute fatty liver during pregnancy(AFLP). METHODS:The deposition of all kinds of im- munoglobulin and complements was observed in three cases of AFLP by immunohistochemical staining. RESULTS:In cases 1 and 2,many rough par- ticles of IgG,C1q or C4c were deposited in he- patic sinusoidal endothelial cells,while Kupffer cells swallowed many positive particles of IgG, IgM,IgA and C1q.Different amounts of C1q and C4d were deposited in the portal area and ves- sel endothelial cells,respectively in case 3,many IgG,IgM and IgA molecules were deposited in hepatic sinusoidal endothelial cells and portal area,but very few complements were deposited. CONCLUSION:The hepatic tissue of AFLP pa- tients has various degrees of humoral immunity reaction,which may be important factors in the development of AFLP.