| 复发卵巢癌腹腔温热化疗联合全身化疗临床研究 |
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| 引用本文： | 周小宁,董克姝,周成英,曹克平. 复发卵巢癌腹腔温热化疗联合全身化疗临床研究[J]. 中国肿瘤临床与康复, 2010, 0(2): 143-145 |
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| 作者姓名： | 周小宁 董克姝 周成英 曹克平 |
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| 作者单位： | 盐城市第一人民医院肿瘤科;盐城市生物工程高等学校; |
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| 摘 要： | 目的探讨复发卵巢癌卡铂腹腔温热化疗联合多西他赛全身化疗的疗效和毒副作用。方法将70例Ⅲ～Ⅳ期复发卵巢癌患者按随机原则选择35例作为治疗组,采用卡铂腹腔温热化疗联合多西他赛全身化疗;35例作为对照组,采用卡铂联合多西他赛全身化疗,并对两组化疗后1,3,5年生存率及毒副作用对照研究,并经统计学χ2检验。结果治疗组1,3,5年生存率分别为88.6%（31/35）、65.7%（23/35）和37.1%（13/35）,对照组分别为80.0%（28/35）、51.4%（18/35）和22.9%（8/35）,两组比较差异无显著性（P〈0.05）。毒副作用主要是骨髓抑制,白细胞下降率（Ⅲ～Ⅳ度）分别为5.7%（2/35）和31.4%（11/35,P〈0.05）。结论复发卵巢癌卡铂腹腔温热化疗联合多西他赛全身化疗的疗效优于卡铂联合多西他赛全身化疗,且毒副作用轻,有利于提高患者的生存率及生存质量。
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| 关 键 词： | 卵巢肿瘤/化学疗法 腹腔温热化疗 卡铂 多西他赛 |
Clinical study of intraperitoneal hyperthermic perfusion chemotherapy (IHPC) and intravenous chemotherapy (IVC) in patients with recurrent ovarian cancer |
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| Affiliation: | ZHOU Xiao-ning,DONG Ke-shu,ZHOU Chen-ying,et al(Department of Tumor,The First People′s Hospital of Yancheng,Jiangsu 224003,China) |
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| Abstract: | Objective To investigate the efficacy and toxicity of intraperitoneal hyperthermic perfusion chemotherapy(IHPC)and intravenous chemotherapy(IVC) in treatment of patients with recurrent ovarian cancer.Methods Seventy patients with recurrent ovarian cancer were divided into two groups according to random principle.Thirty-five cases as trial group underwent IHPC(intraperitoneal hyperthermic perfusion chemotherapy with carboplatin and intravenous docetaxel),and other 35 cases as control group received IVC(carbo... |
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| Keywords: | Ovarian neoplasms/ chemotherapy Intraperitoneal hyperthermic perfusion chemotherapy Carboplatin Docetaxel |
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