慢性心力衰竭患者55例N端脑钠肽前体水平临床意义分析

目的 探讨N端脑钠肽前体（NT-proBNP）水平在慢性心力衰竭患者体内变化的临床意义.方法 选择该院2012年1月至2013年6月收治的慢性心力衰竭患者55例,根据纽约心脏病学会（NYHA）心功能分级分为三组,NYHA Ⅱ级25例纳入Ⅱ组,NYHA Ⅲ级18例纳入Ⅲ组,NYHA Ⅳ级12例纳入Ⅳ组.另选择同期入住的非器质性心脏病患者30例作为对照组.结果 心力衰竭各组患者NT-proBNP、左心室舒张末期内径（LVEDD）、左心室射血分数（LVEF）与对照组比较,差异均有统计学意义（P〈0.05）;以上指标,各心力衰竭组间比较,差异也有统计学意义（P〈0.05）.Ⅲ、Ⅳ组患者NT-proBNP与LVEDD呈正相关[相关系数（r）=0.50、0.71],与LVEF呈负相关（r=-0.47、-0.66）,Ⅱ组患者NT-proBNP与LVEDD、LVEF无关.结论 慢性心力衰竭患者体内NT-proBNP水平变化与心功能呈一致性,可较为准确地反映心力衰竭进程.

Clinical significance analysis of the level of NT-proBNP in 55 patients with chronic heart failure

Objective To analyze the clinical significance of N-terminal pro-brain natriuretic peptide （NT-proBNP） in patients with chronic heart failure. Methods 55 patients with chronic heart failure enrolled in the hospital from 2012 to 2013 were selected and divided into 3 groups according to the classification of New York Hear Association （NYHA） ： 25 cases, who were assessed to be NYHA class II , were regarded as class II group; 18 cases, who were assessed to be NYHA class III, were regarded as class III group;and 12 cases, who were assessed to be NYHA class IV ,were regarded as class 1V group. The other 30 patients with inorganic heart disease at the corresponding period were selected as control group. Results The difference between control groups and other groups with chronic heart failure on NT-proBNP,left ventricular end-diastolic dimension （LVEDD） and left ventricular ejection fraction （LVEF） had statistical significance （P〈O.05） ;and the difference of the above indicators among the three group with chronic heart failure were all statistically significant （P〈O.05）. The NT-proBNP in class m group and class IV group were positive correlation with LVEDD @=0.50 and 0.71 ） and negative correlation with LEVF （r=-0.47 and -0.66）, but the NT-proBNP in class II group had no relationship with LVEDD and LVEF. Conclusion The NT-proBNP in patients with chronic heart disease is consistent with heart function and can accurately reflect the process of heart failure.