| B细胞活化因子/增殖诱导配体与特发性血小板减少性紫癜 |
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| 引用本文： | 冉昌丽,郭静明.B细胞活化因子/增殖诱导配体与特发性血小板减少性紫癜[J].医学综述,2014(3):420-423. |
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| 作者姓名： | 冉昌丽 郭静明 |
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| 作者单位： | 三峡大学第一临床医学院宜昌市中心人民医院血液内科,湖北宜昌443003 |
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| 摘 要： | 特发性血小板减少性紫癜(ITP)是目前临床最为常见的自身免疫性疾病。其发病机制多认为与自身抗体介导的血小板破坏、T细胞亚群功能与凋亡异常、细胞毒性T细胞介导的细胞毒作用等有关。而最新研究表明,B细胞活化因子/增殖诱导配体的过度表达在ITP发病机制中起到重要作用,但具体作用不清。抑制其过度表达从而治疗ITP,还有待进一步研究。
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| 关 键 词： | B细胞活化因子 增殖诱导配体 特发性血小板减少性紫癜 |
The Relationship between B Cell Activation Factor/Proliferation-Inducing Ligand with Idiopathic Thrombocytopenic Purpura |
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| Institution: | RAN Chang-li, GUO Jing-ming. ( The First College of Clinical Science, China Three Gorges University, Yichang 443003, China) |
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| Abstract: | Idiopathic thrombocytopenic pulpura（ITP） is currently the most common autoimmune disease in clinical. The most popular opinion on its pathogenesis is that it is related to the platelct destruction mediated by antibody, the abnormality of function and apoptosis of T cell subpopulation, the CTL cell mediated cytotox- icity,and so on. The latest research shows that overexpression of B cell activation factor and proliferation- inducing ligand play an important role in the pathogenesis of ITP, but the concrete effect is not clear. Inhibi- ting the excessive expression to treat ITP still needs further study. |
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| Keywords: | B cell activating factor Proliferation-inducing ligand Idiopathic thrombocytopenic purpura |
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