血清性激素结合球蛋白水平的降低与代谢综合征发生的相关性分析

目的探讨血清性激素结合球蛋白(SHBG)与代谢综合征(MS)发生之间的相关性。方法收集2011年1月至2013年12月在本院接受体检者398例,根据是否合并MS分为MS组和非MS组,比较两组的临床特征及血清性激素结合球蛋白水平。结果 MS组的SHBG水平为(19±15)nmol/L,显著低于非MS组的(35±34)nmol/L),差异有统计学意义(P0.05);SHBG与甘油三酯(TG)、胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(FIN)、空腹血糖(FBG)以及舒张压(DBP)呈显著负相关性,而与高密度脂蛋白胆固醇(HDL-C)呈显著正相关性,差异有统计学意义(P0.05);Logistic回归分析显示,校正性别、年龄、腰臀比、体重指数(BMI)及HOMA-IR后,男性及女性的SHBG与MS的发生风险呈显著负相关(男:OR=0.897,95%CI 0.875~0.919,P0.05;女:OR=0.985 CI 0.930~1.040,P0.05)。根据SHBG三分位数从低到高将患者分为A、B、C 3组,A组患病率为70.0%(84/120),B组为51.1%(70/137),C组为24.1%(34/141),差异有统计学意义(P0.05),可见随着SHBG水平的升高,MS的患病率逐渐下降。结论无论是男性还是女性中,SHBG降低与MS的发生及发展具有密切关系,且随着SHBG水平降低,MS发病率逐渐上升。

Correlation analysis between the reduce of serum sex hormone binding globulin and occurrence of metabolic syndrome

Objective To investigate the correlation between serum sex hormone binding globulin （SHBG） and metabolic syndrome （MS）. Methods 398 cases of physical examination in our hospital from January 2011 to December 2013 were retrospectively analyzed. All cases were divided into MS and non-MS group according to whether the merger MS. The clinical features and serum sex hormone-binding globulin levels of two groups were compared. Results SHBG levels of MS group was （19±15）nmol/L, significantly lower than that of the non- MS group （35±34）nmol/L,P〈0.05. SHBG showed significant negative correlation with TG, HOMA-IR, FIN, FBG and DBP, and significant positive correlation with HDL- C（P〈0.05）. Logistic results showed SHBG of men and women had significant negative correlation with risk of MS （male, OR=0.897,95%CI 0.875-0.919, P〈0.05 ; female, OR=0.985 95%CI 0.930-1.040, P〈0.05）, after adjusted the sex, age, waist-hip ratio, BMI and HOMA-IR. According to SHBG level, the patients were divided into A, B, C three groups from low to high. Prevalence of group A was 70.0% （84/120）, group B was 51.1%（70/137）,and group C was 24.1% （34/ 141）,showing significant differences （P〈0.05）,and a trend of gradually decrease with the increasing of SHBG levels. Conclusion In both men and women, there is a close relationship between reduce of SHBG level and the occurrence and development of MS, and the prevalence of MS is gradually decreased with the increasing of SHBG levels.