Comparison of saline and streptokinase-streptodornase in the treatment of leg ulcers

Summary In 31 patients with leg ulcers the wounds were randomly allocated to treatment either with a solution of streptokinase plus streptodornase in saline or physiological saline alone.The occurrence of pus and debris in the wounds was evaluated by a blinded investigator at the initiation of treatment and on Days 5, 10 and 15.In 12 out of 13 patients treated with the streptokinase-streptodornase solution and in 8 out of 16 saline-treated patients the wounds were clean by Day 10.