晚发性佝偻病敏感诊断指标临床分析

目的探讨骨密度B超、血钙、磷、碱性磷酸酶、X线对晚发性佝偻病临床诊断的敏感性。方法采用骨密度B超仪、全自动生化分析仪、X线对昆明市儿童医院儿童保健门诊139例晚发性佝偻病患儿进行骨密度、血钙、磷、碱性磷酸酶、左手腕摄片检查。结果晚发性佝偻病患儿骨密度B超检测参数Z值和百分位数比较,治疗前后有显著性差异(P<0.05),治疗有效;血生化检测血钙、碱性磷酸酶比较,治疗前后结果无显著性差异(P>0.05)。治疗前后Z值呈负相关(r=-0.67),百分位数呈高度正相关(r=0.75)。结论骨密度B超检测对晚发性佝偻病的诊断较传统佝偻病诊断手段具有一定的敏感性、特异性,且检测方便,无痛、无损伤性,易于普及推广,对晚发性佝偻病的早期诊断、治疗起到积极的作用。

Sensitive Indicators of Clinical Diagnosis for Late-onset Rickets

Objective To investigate the sensitivity of quantitative ultrasound bone densitometry,calcium,phosphorus,alkaline phosphatase,X-ray of late-onset rickets.Methods Bone mineral density,calcium,phosphorus,alkaline phosphatase were measured and left hand ray examinations in 139 cases of children with late-onset rickets.Results Z-store for bone mineral density（BMD）was significant difference（P0.05） compared before and after treatment;there were no significant difference（P0.05） in blood serum calcium,alkaline phosphatase.Z-score showed a negative correlation（r=-0.67）,percentile was positively correlated（r=0.75）.Conclusion Quantitative ultrasound bone densitometry is a easy way for diagnosis of late-onset rickets than the traditional diagnostic tools with a certain sensitivity and specificity.