凋亡基因蛋白Bcl-2、Bax,p53在子宫内膜异位症组织中的表达及相关研究

目的探讨凋亡调节基因Bcl-2、Bax、p53在子宫内膜异位症发生、发展中的作用。方法免疫组织化学SP法检测子宫内膜异位症患者60例盆腔异位内膜及在位内膜和40例正常子宫内膜组织中Bcl-2、Bax、p53的表达。结果 Bcl-2在异位内膜组表达强于在位内膜及对照组,差异有统计学意义(P值均<0.05),Bax在异位内膜组的染色强度低于在位内膜组和对照组,差异有统计学意义(P值均<0.05);p53在正常子宫内膜及子宫内膜异位症患者在位内膜中均呈阴性表达,在子宫内膜异位症患者异位内膜中的阳性表达率为20%,表达水平显著高于正常子宫内膜及在子宫内膜,差异有统计学意义(P<0.05)。结论凋亡调节基因Bcl-2、Bax、p53在子宫内膜异位症发生、发展中发挥重要作用。

Apoptotic Protein Bcl-2, Bax, p53 in Endometrial Endometriosis Tissues and Related Research

Objective To investigate the regulation of apoptosis gene Bcl-2, Bax, p53 in the development of endometriosis in the role. Methods Immunoh istochemistry SP method detected in patients with endometriosis and 60 cases of pelvic endometriosis and 40 normal eutopic endometrial tissue in the Bcl-2, Bax, p53 expression. Results Bcl-2 expression in ectopic endometrium and eutopic stronger than the control group,the difference was statistically significant（Pvalues0.05）,Bax staining in ectopic endometrium than the reign of the intensity of film group and the control group,the difference was statistically significant（（Pvalues0.05）; p53 in normal endometrium and endometriosis eutopic endometrium was negative in endometriosis ectopic endometrium of patients with positive expression rate was 20%,expression levels were significantly higher than in normal endometrium and endometrium,the difference was statistically significant（P0.05）. Conclusion Apoptosis regulator Bcl-2 gene , Bax, p53 in the development of endometriosis play an important role.