| 不同组方金银冠心汤对急性心肌缺血小鼠的保护作用比较研究 |
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| 引用本文： | 柳振宇.不同组方金银冠心汤对急性心肌缺血小鼠的保护作用比较研究[J].延边医学院学报,2009,32(1):36-38. |
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| 作者姓名： | 柳振宇 |
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| 作者单位： | 延边大学中医学院,吉林,延吉,133000
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| 摘 要： | 目的]观察不同组方金银冠心汤对小鼠急性心肌缺血的影响.方法]采用夹闭气管的方法制作小鼠心肌缺氧模型,观察各组小鼠心电消失时间;采用Iso皮下注射方法制作小鼠急性心肌缺血模型,观察各组小鼠常压耐缺氧存活时间.结果]改良金银冠心汤组(金银花、丹参、玄参、当归及甘草各30 g)小鼠气管夹闭后心电消失时间及Iso诱发小鼠急性心肌缺血常压耐缺氧存活时间均明显延长.结论]金银冠心汤的加减方对急性心肌缺血具有保护作用.
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| 关 键 词： | 心肌缺血 金银冠心汤 小鼠 |
Comparative study of protective effects of different recipe of the Flos Lonicerae compound preparation for acute myocardial ischemia in mice |
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| LIU Zhen-yu.Comparative study of protective effects of different recipe of the Flos Lonicerae compound preparation for acute myocardial ischemia in mice[J].Journal of Medical Science Yanbian University,2009,32(1):36-38. |
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| Authors: | LIU Zhen-yu |
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| Institution: | LIU Zhen-yu(Yanbian University College of Traditional Chinese Medicine, Yanji 133000, Jilin, China) |
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| Abstract: | OBJECTIVE To observe the effects of different recipe of the Flos Lonicerae compound preparation （FLCP） for acute myocardial ischemia in mice. METHODS The model of acute myocardial ischemia in mice was made by closing trachea and by subcutaneous injection of the Iso to observe the disappeared time of ECG and survival time in normobaric hypoxia of mice in each group, respectively. RESULTS The group with modified recipe of FLCP （30 g of each the Flos Lonicerae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Radix Angelicae Sinensis and Radix Glycyrrhizae ） was significantly prolonged the disappeared time of ECG and survival time in normobaric hypoxia of mice with closing trachea and the Iso-induced acute myocardial ischemia. CONCLUSION The modified recipe of FLCP has protective effects for the acute myocardial ischemia in mice. |
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| Keywords: | myocardial ischemia flos lonicerae compound preparation mice |
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