阿司匹林肠溶片联合雌二醇片/雌二醇地屈孕酮片复合包装改善薄型子宫内膜的临床研究

目的研究阿司匹林肠溶片联合雌二醇片/雌二醇地屈孕酮片复合包装在改善薄型子宫内膜的临床效果。方法选择2013年1月—2015年6月在衡水市第二人民医院就诊的薄型子宫内膜患者160例,随机分为对照组和治疗组,每组各80例。对照组口服雌二醇片/雌二醇地屈孕酮片复合包装,每28天为1个周期。前14 d每日口服1片砖红色片(内含雌二醇2mg);后14 d,每日口服1片黄色片(内含雌二醇2 mg和地屈孕酮10 mg)。治疗组在对照组的治疗基础上口服阿司匹林肠溶片,1片/d,1次/d,至当月排卵后的第7天停止服药。两组均连续治疗3个周期。观察两组治疗前后子宫内膜的微血管密度(MVD)、子宫内膜厚度、整合素β3、阻力指数(RI)、搏动指数(PI)、动脉血流收缩期峰值(S)和舒张末期的谷值(D)比值(S/D)的变化情况。比较两组妊娠情况。结果治疗后,两组子宫内膜MVD和厚度、整合素β3均较治疗前有所增加,两组RI、PI、S/D均较治疗前有所降低,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,对照组和治疗组的妊娠率分别为27.50%、53.75%,两组比较差异具有统计学意义(P0.05)。结论阿司匹林肠溶片联合雌二醇片/雌二醇地屈孕酮片复合包装能够显著增加薄型子宫内膜患者的子宫内膜厚度,改善子宫血流情况,增加妊娠率,具有一定的临床推广应用价值。

Clinical study on Aspirin Enteric-coated Tablets combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets in improvement of thin endometrium

Objective To investigate the clinical effect of Aspirin Enteric-coated Tablets combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets in improvement of thin endometrium. Methods Patients (160 cases) with thin endometrium in the Second People’s Hospital of Hengshui from January 2013 to June 2015 were randomly divided into control and treatment groups, and each group had 80 cases. The patients in the control group were po administered with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets, and every 28 d was as one course. Before 14 d, the patients in the control group were po administered with brick red tablets (containing 2 mg estradiol), one tablet/time, once daily, and after 14 d, they were po administered with yellow tablets (containing 2 mg estradiol and 10 mg progesterone), one tablet/time, once daily. The patients in the treatment group were po administered with Aspirin Enteric-coated Tablets until day 7 after ovulation on the basis of the control group, one tablet/time, once daily. The patients in two groups were treated for three courses. After treatment, the changes of the endometrial MVD, endometrial thickness, integrin β3, RI, PI, and S/D in two groups before and after treatment were compared. Results After treatment, endometrial MVD, endometrial thickness, and integrin β3 in two group were significantly increased, and RI, PI, and S/D in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05).And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the pregnancy rates in the control and treatment groups were 27.50%and 53.75%, respectively, and there were differences between two groups (P < 0.05). Conclusion Aspirin Enteric-coated Tablets combined with Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets can significantly increase the endometrium thickness in patients with endometrial thickness, and can improve uterine blood flow, also can increase the pregnancy rate, which has a certain clinical application value.