丹参多酚酸盐联合左旋氨氯地平治疗冠心病心绞痛的疗效观察

目的观察丹参多酚酸盐联合左旋氨氯地平治疗冠心病心绞痛的临床疗效。方法选取2014年1月—2015年10月长武县人民医院收治的冠心病心绞痛患者82例,随机分为对照组(40例)和治疗组(42例)。对照组口服苯磺酸左旋氨氯地平片,2.5 mg/次,1次/d。治疗组在对照组基础上静脉滴注注射用丹参多酚酸盐,200 mg加入到5%葡萄糖溶液250 m L中,1次/d。两组患者均治疗2周。观察两组的临床疗效,比较两组患者的临床症状、心电图改善和血液流变学指标情况。结果治疗后,对照组和治疗组的总有效率分别为67.50%、88.10%,两组比较差异有统计学意义(P0.05)。治疗后,对照组和治疗组的心电图改善总有效率分别为67.50%、88.10%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者的心绞痛发作次数和心绞痛持续时间均降低,同组治疗前后差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者的全血黏度、血浆黏度、血小板黏附率均显著下降,同组治疗前后差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论丹参多酚酸盐联合左旋氨氯地平治疗冠心病心绞痛具有较好的临床疗效,能缓解临床症状,改善血液流变学,具有一定的临床推广应用价值。

Clinical observation of salvianolate combined with levamlodipine in treatment of angina pectoris of coronary heart disease

Objective To observe the clinical effect of salvianolate combined with levamlodipine in treatment of angina pectoris of coronary heart disease. Methods Patients (82 cases) with angina pectoris of coronary heart disease in Changwu County People''s Hospital from January 2014 to October 2015 were randomly divided into the control group (40 cases) and treatment group (42 cases). Patients in the control group were po administered with Levamlodipine Besylate Tablets, 2.5 mg/time, once daily. Patients in the treatment group were iv administered with Salvianolate for injection on the basis of the control group, 200 mg added to 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms, electrocardiogram improvement, and blood rheology indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 67.50% and 88.10%, respectively, and there was difference between two groups (P<0.05). After treatment, the efficacies of electrocardiogram improvement in the control and treatment groups were 67.50% and 88.10%, respectively, and there was difference between two groups (P<0.05). After treatment, angina attack frequency and angina pectoris duration in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, whole blood viscosity, plasma viscosity, and platelet adhesion rate in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Salvianolate combined with levamlodipine has clinical curative effect in treatment of angina pectoris of coronary heart disease, and can relieve clinical symptom, improve blood rheology, which has a certain clinical application value.