某院肝炎或肝硬化患者质子泵抑制药应用合理性评价

摘 要 目的：调查某院肝炎或肝硬化患者质子泵抑制药的使用情况，并进行合理性评价。方法: 对某院2013~2014年诊断为“肝炎”或“肝硬化”的住院患者质子泵抑制药的应用情况进行回顾性分析，并对使用合理性进行评价。 结果: 共收集到211份病历，使用质子泵抑制药192例，使用率91%；不合理用药62例，占总病例数的29.3%；用药不合理主要表现为用药疗程过长（24.5%），预防用药指征不充分（5.7%），无目的用药（2.6%）。结论:肝炎或肝硬化患者质子泵抑制药的不合理使用十分普遍，临床药师应加强药学监护，促进合理用药。

Application and Rationality Evaluation of Proton Pump Inhibitors Used in Patients with Cirrhosis or Hepatitis in One Hospital

ABSTRACT Objective: To investigate the use of proton pump inhibitors (PPIs) in the patients with cirrhosis or hepatitis in one hospital and evaluate the use rationality. Methods: A retrospective study was carried out on 211 patients with the diagnosis of hepatitis or cirrhosis in the infectious disease ward between 2013 and 2014, and the use rationality of PPIs was evaluated.Results:A total of 211 cases were inspected, and among them, 192 ones were treated with PPIs (91%) with 62 ones treated with PPIs irrationally, which accounted for 29.3% of the total cases. The main irrational use of PPIs was long treatment course (24.5%), inadequate prophylaxis indications (5.7%) and purposeless use (2.6%). Conclusion:Irrational use of PPI is common in hepatitis or cirrhosis patients. Clinical pharmacists should strengthen pharmaceutical care to improve the rational drug use.