硅油并发性白内障和年龄相关性白内障晶状体上皮细胞中凋亡因子的表达差异

目的:分析硅油并发性白内障和年龄相关性白内障晶状体上皮细胞中凋亡因子的表达差异.方法:将我院2014-03/2016-03收治的硅油并发性白内障患者50例50眼作为研究组,另选同期收治年龄相关性白内障患者50例50眼作为对照组,两组患者均已如实掌握此次研究方案具体内容并签署知情同意书后对其晶状体上皮细胞中凋亡因子的表达进行测定和比较.结果:研究组Bcl-2蛋白表达阳性率92％、Bax蛋白表达阳性率100％、Caspase-3蛋白表达阳性率100％,而同期对照组Bcl-2蛋白表达阳性率80％、Bax蛋白表达阳性率84％、Caspase-3蛋白表达阳性率82％,组间差异具有统计学意义(P＜0.05).结论:硅油并发性白内障晶状体上皮细胞中凋亡因子的表达显著高于年龄相关性白内障,提示晶状体上皮细胞中部分凋亡因子全程参与硅油并发性白内障的发生发展过程.

Expression of apoptosis factor in the lens epithelial cells of the patients with silicone oil complicated cataract and age-related cataract

AIM: To analyze the expression of apoptosis factor in cataract and age-related cataract lens epithelial cells.

METHODS: A total of 50 cases(50 eyes)of concurrent silicone oil cataract patients as study group and the same period of 50 cases(50 eyes)of age-related cataract patients as control group were selected in our hospital during Mar. 2014 to Mar. 2016. In the determination of two groups of patients had been accurately grasped the specific content of the research program and signed informed consent book of the lens epithelial cells apoptosis factor expression. They were measured and compared.

RESULTS: Study group of Bcl-2 protein expression positive rate was 92%. Bax protein expression positive rate was 100%. The expression of caspase-3 protein expression positive rate was 100%. Compared with the control group, the expression of bcl-2 expression positive rate of 80%. Bax protein expression positive rate of 84%. Caspase-3 protein expression positive rate of 82%. Difference between the two groups were statistically significant(P<0.05).

CONCLUSION: Concurrent silicone oil cataract lens epithelial cells apoptosis factor expression is significantly higher than that of age-related cataract. A clinical lens epithelial cells apoptosis factors of full participation in the silicone oil cataract extraction in the development and progression is prompted.