超微血管成像技术评估类风湿活动性关节炎:与CDFI和CEUS对比

目的 通过与CDFI和CEUS比较，探讨超微血管成像（SMI）评估类风湿性关节炎（RA）患者腕关节滑膜血流信号分级的临床应用。方法 收集100例RA患者（左侧或右侧腕关节，共100个腕关节）。采用高频超声观察腕关节的滑膜厚度。再分别采用CDFI、SMI和CEUS对滑膜增生最严重部位的血流信号进行分级评估，计算血流信号显示率，并进行统计学分析。结果 SMI和CEUS的滑膜内血流信号显示率均高于CDFI[92.00%（92/100）、92.00%（92/100）、80.00%（80/100）]。CDFI与SMI评价增厚滑膜内血流信号分级的差异有统计学意义（P<0.01）。CEUS与SMI评价增厚滑膜内血流信号分级的一致性高（Kappa=0.76，P<0.05）。结论 SMI在观察RA患者增生滑膜血流信号方面优于CDFI，并且与CEUS具有很好的一致性。SMI可评估RA活动性，且安全、简便、高效、经济。

Superb microvascular imaging technology in evaluation on rheumatoid activity arthritis: Compared with CDFI and CEUS

Objective To assess the clinical application of superb microvascular imaging (SMI) in diagnosis of wrist joints'' synovial membrane of rheumatoid arthritis (RA) patients, which comparing with the CDFI and CEUS.Methods Totally 100 patients with RA were enrolled (left or right wrist joints, totally 100 wrist joints). The thickness of synovial membrane of wrist joint was checked by high frequency ultrasound. Then the blood flow signal was classified in the most serious position of synovium hyperplasia by CDFI, SMI and CEUS respectively, and the rate of blood flow signals was calculated. The statistical analysis was carried out.Results The rate of blood flow signal of SMI and CEUS were both higher than that of CDFI (92.00%[92/100],92.00%[92/100],80.00%[80/100]). The difference of blood flow signal classification in hyperplasia synovium evaluated by CDFI and SMI had statistical significance (P<0.01). CEUS and SMI had high consistency in evaluation of blood flow signal classification in hyperplasia synovium (Kappa=0.76, P<0.05).Conclusion SMI is superior to CDFI in observation of the blood flow signals in hyperplasia synovium of RA patients, and SMI has good consistency with CEUS. SMI can be used to evaluate the activity of RA, and is safe, convenient, efficient and cheap.