滑膜炎颗粒联合玻璃酸钠治疗创伤性膝关节滑膜炎的临床研究

目的探讨滑膜炎颗粒联合玻璃酸钠注射液治疗创伤性膝关节滑膜炎的临床疗效。方法选取2015年5月—2016年4月在汉中市中心医院接受治疗的创伤性膝关节滑膜炎患者80例,根据治疗方案的差别分为对照组和治疗组,每组各40例。对照组患者关节腔注射玻璃酸钠注射液,2 m L/次,1次/周。治疗组在对照组的基础上口服滑膜炎颗粒,1袋/次,3次/d。两组患者均连续治疗5周。观察两组的临床疗效,同时比较两组治疗前后VAS评分、HSS评分、症状体征积分、肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)和白介素-6(IL-6)水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者VAS评分降低,而HSS评分升高,同组治疗前后差异具有统计学意义(P0.05);且治疗组VAS和HSS评分的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者肿胀评分、疼痛评分、活动度评分和临床症状积分均较治疗前显著降低,同组治疗前后差异具有统计学意义(P0.05);且治疗组上述症状体征积分降低更明显,两组比较差异有统计学意义(P0.05)。治疗后,两组TNF-α、IL-1、和IL-6水平显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组的降低程度优于对照组,两组比较差异有统计学意义(P0.05)。结论滑膜炎颗粒联合玻璃酸钠治疗创伤性膝关节滑膜炎的效果显著,可明显改善患者临床症状,降低炎性因子水平,具有一定的临床推广应用价值。

Clinical study on Huamoyan Granules combined with sodium hyaluronate in treatment of traumatic synovitis of knee joint

Objective To evaluate the clinical efficacies of Huamoyan Granules combined with sodium hyaluronate in treatment of traumatic synovitis of knee joint. Methods Patients (80 cases) with traumatic synovitis of knee joint in Hanzhong Central Hospital from May 2015 to April 2016 were divided into control and treatment groups based on different treatments, and each group had 40 cases. The patients in the control group were intra-articular injection administered with Sodium Hyaluronate Injection, 2 mL/time, once a week. The patients in the treatment group were po administered with Huamoyan Granules on the basis of the control group, 1 bag/time, three times daily. The patients in two groups were treated for 5 weeks. After treatment, clinical efficacies were evaluated, and VAS scores, HSS scores, symptom and sign scores, TNF-α, IL-1, and IL-6 in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00%and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, VAS scores in two groups were decreased, but HSS scores were increased, and the difference was statistically significant in the same group (P<0.05). And the improvement of VAS and HSS scores in the treatment group were better than those in the control group, with significant difference between two groups (P<0.05). After treatment, swelling scores, pain scores, activity scores, and symptom and sign scores in two groups were lower than those in the same group before treatment, and there were differences in the same group (P<0.05). And these symptom and sign scores in the treatment group were lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, TNF-α, IL-1, and IL-6 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decrease degree of these observational indexes in treatment group was better than those in control group, with significant difference between two groups (P<0.05).Conclusion Huamoyan Granules combined with sodium hyaluronate in treatment of traumatic synovitis of knee joint has a significant clinical efficacy, can obviously improve the clinical symptoms and reduce the expression of inflammatory factor, which has a certain clinical application value.