固本益肠片联合布拉氏酵母菌散和维生素C治疗小儿抗生素相关性腹泻的临床研究

目的探讨固本益肠片联合布拉氏酵母菌散和维生素C治疗小儿抗生素相关性腹泻的临床疗效。方法选取2013年5月—2015年5月延安大学附属医院收治的抗生素相关性腹泻患儿120例,随机分为对照组和治疗组,每组各60例。对照组口服布拉氏酵母菌散,0.25 g/次,患儿≥3岁:2次/d,患儿3岁:1次/d。且对照组还口服维生素C颗粒,0.5 g/次,1次/d。治疗组在对照组的基础上口服固本益肠片,1.28 g/次,3次/d。两组患儿均治疗2周。观察两组的临床疗效及复发率,同时比较临床症状、免疫球蛋白G(Ig G)、免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)及T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)的变化。结果治疗后,对照组和治疗组的总有效率分别为73.3%、93.3%,两组比较差异有统计学意义(P0.05)。治疗后,对照组和治疗组的复发率分别为18.3%、5.0%,两组比较差异有统计学意义(P0.05)。治疗后,治疗组腹泻缓解时间、发热缓解时间、恶心缓解时间、呕吐缓解时间及治愈时间较对照组均缩短,两组比较差异具有统计学意义(P0.05)。治疗后,对照组和治疗组Ig G、Ig A、Ig M、CD3+、CD4+、CD8+及CD4+/CD8+均明显升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的升高程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论固本益肠片联合布拉氏酵母菌散和维生素C治疗小儿抗生素相关性腹泻具有较好的临床疗效,能降低复发率,缩短症状缓解时间与治疗时间,增强患儿免疫功能,具有一定的临床推广应用价值。

Clinical study on Guben Yichang Tablets combined with Saccharomyces Boulardii Sachets and vitamin C in treatment of antibiotic-associated diarrhea in children

Objective To explore the clinical effect of Guben Yichang Tablets combined with Saccharomyces Boulardii Sachets and vitamin C in treatment of antibiotic-associated diarrhea in children. Methods Children (120 cases) with antibiotic-associated diarrhea in Yan’an University Affiliated Hospital from May 2013 to May 2015 were randomly divided into control and treatment groups, and each group had 60 cases. Children in the control group were po administered with Saccharomyces Boulardii Sachets, 0.25 g/time, age≥ 3 years: twice daily, age< 3 years: once daily. And children in the control group were also po administered with Vitamin C Granules, 0.5 g/time, once daily. Children in the treatment group were po administered with Guben Yichang Tablets on the basis of the control group, 1.28 g/time, three times daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms, IgG, IgA, IgM, and T cell subsets (CD3+, CD4+, CD8+, and CD4+/CD8+) in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.3%and 93.3%, respectively,and there was difference between two groups (P<0.05). After treatment, the recurrence rate in the control and treatment groups were 18.3% and 5.0%, respectively, and there was difference between two groups (P < 0.05). After treatment, diarrhea relief time, fever relief time, nausea relief time, vomiting relief time, and cure time in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, IgG, IgA, IgM, CD3+, CD4+, CD8+, and CD4+/CD8+in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guben Yichang Tablets combined with Saccharomyces Boulardii Sachets and vitamin C has clinical curative effect in treatment of antibiotic-associated diarrhea in children, and can reduce recurrence rate, shorten clinical symptoms relief time and cure time, enhance immune function, which has a certain clinical application value.