甜梦口服液联合右佐匹克隆治疗脑梗死后失眠症的疗效观察

目的探讨甜梦口服液联合右佐匹克隆治疗脑梗死后失眠症临床疗效。方法选取2014年7月—2015年7月在铁岭市中心医院神经内科接受治疗的脑梗死后失眠症患者96例,随机分为对照组和治疗组,每组各48例。对照组患者睡前口服右佐匹克隆片,初始剂量1.5 mg/次,3 d后3 mg/次。治疗组在对照组基础上口服甜梦口服液,20 m L/次,3次/d。两组患者均治疗1个月。观察两组的临床疗效,比较两组改良爱丁堡–斯堪的那维亚卒中量表(MESSS)评分、匹兹堡睡眠质量量表(PSQI)评分和综合医院焦虑抑郁量表(HAD)评分情况。结果治疗后,对照组和治疗组的总有效率分别为83.33%、95.83%,两组比较差异有统计学意义(P0.05)。治疗后,两组MESSS评分、PSQI评分和HAD评分均明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论甜梦口服液联合右佐匹克隆治疗脑梗死后失眠症具有较好的临床疗效,有利于患者神经功能恢复,提高患者睡眠质量,具有一定的临床推广应用价值。

Clinical observation of Tianmeng Oral Liquid combined with eszopiclone in treatment of post-stroke insomnia

Objective To investigate the clinical effect of Tianmeng Oral Liquid combined with eszopiclone in treatment of post-stroke insomnia. Methods Patients (96 cases) with post-stroke insomnia in Department of Neurology of Tieling Central Hospital from July 2014 to July 2015 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Eszopiclone Tablets before bedtime, the initial dose was 1.5 mg/time, and 3 mg/time after 3 d. Patients in the treatment group were po administered with Tianmeng Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and MESSS score, PSQI score, and HAD score in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 95.83%, respectively, and there was difference between two groups (P<0.05). After treatment, MESSS score, PSQI score, and HAD score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Tianmeng Oral Liquid combined with eszopiclone has clinical curative effect in treatment of post-stroke insomnia, and contribute to the recovery of neurological function, improve the quality of sleep, which has a certain clinical application value.