胃苏颗粒联合铝碳酸镁治疗反流性胃炎的临床研究

目的探讨胃苏颗粒联合铝碳酸镁治疗反流性胃炎的临床疗效。方法选取2015年3月—2016年3月榆林市中医医院收治的反流性胃炎患者80例,随机分为对照组和治疗组,每组各40例。对照组口服铝碳酸镁片,2片/次,3次/d。治疗组在对照组基础上口服胃苏颗粒,3袋/次,3次/d。两组患者均治疗2周。观察两组的临床疗效,比较两组的临床症状、生活质量、血管活性肠肽(VIP)及白细胞介素-6(IL-6)的变化。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者临床症状评分和胃食管返流疾病生活质量(GERD-HRQL)评分均显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组这些观察指标的降低程度明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者血清VIP及IL-6水平均显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组这些观察指标的降低程度明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论胃苏颗粒联合铝碳酸镁治疗反流性胃炎具有较好的临床疗效,可改善临床症状,降低炎症反应,提高生活质量,具有一定的临床推广应用价值。

Clinical study on Weisu Granules combined with hydrotalcite in treatment of reflux gastritis

Objective To explore the clinical effect of Weisu Granules combined with hydrotalcite in treatment of reflux gastritis. Methods Patients (80 cases) with reflux gastritis in Chinese Medicine Hospital of Yulin from March 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Hydrotalcite Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Weisu Granules on the basis of the control group, 3 bag/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the changes of clinical symptoms, quality of life, vasoactive intestinal peptide (VIP), and IL-6 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of clinical symptoms and GERD-HRQL in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of VIP and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Weisu Granules combined with hydrotalcite has the clinical curative effect in treatment of reflux gastritis, and can improve clinical symptoms, decrease inflammatory reaction, enhance quality of life, which has a certain clinical application value.