热淋清颗粒联合多沙唑嗪和左氧氟沙星治疗慢性细菌性前列腺炎的疗效观察

目的观察热淋清颗粒联合多沙唑嗪和左氧氟沙星治疗慢性细菌性前列腺炎的疗效。方法选取2013年8月—2015年2月海南省农垦那大医院收治的慢性细菌性前列腺炎患者82例,随机分为对照和组治疗组,每组各41例。对照组患者口服甲磺酸多沙唑嗪片,2 mg/次,1次/d;并口服左氧氟沙星片,0.5 g/次,1次/d。治疗组在对照组基础上口服热淋清颗粒,1袋/次,3次/d。两组患者连续治疗1个月。观察两组的临床疗效,比较两组前列腺液白细胞计数(EPS-WBC)和慢性细菌性前列腺炎症状评分(NIH-CPSI)变化情况。结果治疗后,对照组和治疗组的总有效率分别为80.49%、95.12%,两组比较差异有统计学意义(P0.05)。两组EPS-WBC和NIH-CPSI均显著下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论热淋清颗粒联合多沙唑嗪和左氧氟沙星治疗慢性细菌性前列腺炎具有较好的临床疗效,可改善临床症状,安全性较好,具有一定的临床推广应用价值。

Clinical observation of Relinqing Granules combined with doxazosin and levofloxacin in treatment of chronic bacterial prostatitis

Objective To observe the clinical effect of Relinqing Granules combined with doxazosin and levofloxacin in treatment of chronic bacterial prostatitis. Methods Patients (82 cases) with chronic bacterial prostatitis in Hainan Nongken Nada Hospital from August 2013 to February 2015 were randomly divided into the control and treatment groups, and each group had 41 cases. Patients in the control group were po administered with Doxazosin Mesylate Tablets, 2 mg/time, once daily. And patients in the control group were also po administered with Levofloxacin Tablets, 0.5 mg/time, once daily. Patients in the treatment group were po administered with Relinqing Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and the changes of EPS-WBC and NIH-CPSI in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.49% and 95.12%, respectively, and there was difference between two groups (P<0.05). After treatment, EPS-WBC and NIH-CPSI were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Relinqing Granules combined with doxazosin and levofloxacin has clinical curative effect in treatment of chronic bacterial prostatitis, and can improve clinical symptoms, with good safety, which has a certain clinical application value.